DEVELOPMENT AND VALIDATION OF DAPOXETINE IN PURE AND SOLID DOSAGE FORM BY HPTLC METHOD
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2014, Vol 4, Issue 2
Abstract
An HPTLC method has been developed for the estimation of Dapoxetine in bulk and solid dosage form. It employs pre coated plates by using silica gel 60 F 254(2×10 cm, thick ness of layer 0.2 mm) as stationary phase and the mobile phase comprises of Acetonitrile: Ethyl acetate (9:1v/v). The developing solvent was run up to 50 mm in Camag chamber. Densitometic scanning was then performed with Camag TLC scanner-3 at λ max 292 nm. The Rf value was found to be 0.54. The linearity and range for Dapoxetine was found to be 100-600ng/µl and the method was found to be accurate with 99.16% -100.33% with %RSD 0.5936. The %RSD for interday and intraday precision was 0.304389 and 0.5471 respectively. Correlation coefficient was found to be 0.9995 and the method was validated as per ICH guide lines
Authors and Affiliations
G Abirami* , T Vetrichelvan , M Madanmohan
Keywords
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