SOLUBILITY AND DISSOLUTION ENHANCEMENT OF ACECLOFENAC BY SOLID DISPERSION TECHNIQUE
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2016, Vol 6, Issue 1
Abstract
ABSTRACT Aceclofenac an analgesic and anti-inflammatory drug used intreatment of Osteo arthritis, rheumatoid arthritis and ankylosing spondylitis.Aceclofenac solid dispersions were prepared using hydrophillic polymers such as polyethylene glycol- 4000, polyethylene glycol-6000 and Polyvinyl Pyrrolidone in the ratio of 9:1, 7:3 and 1:1 by solvent evaporation technique. The prepared formulations were evaluated for number of parameters like solubility, drug content uniformity, drug-polymer interactions, differential scanning calorimetry, X-ray diffractogram study showed the reduced number of peaks and decrease intensity of the peaks in the formulations, this suggests that the crystalline nature of the drug was converted to amorphous form, which is the reason for the higher solubility, faster dissolution rate and improved bioavailability of the drug when it is formulating in the form of solid dispersion. Drug Aceclofenac and its various formulations were subjected to scanning electron microscopy studies. The results showed the conversion of crystalline nature of the drug to amorphous form, which indicates enhanced solubility, dissolution rate and bioavailability of the drug. The in vitro release study was carried out on plain pure drug Aceclofenac and various solid dispersion formulations by employing pH 6.8 phosphate buffer as a dissolution medium. This shows an increased release of the drug from the dispersions in comparison to pure Aceclofenac drug. In vitro data of all formulations was subjected to first order plots, the graphs plotted were fairly linear and the ‘r’ values of all the formulations were very close to one, indicating the release mechanism followed first order kinetics. Keywords: Analgegic, Ankylosing spondylitis, Dispersion
Authors and Affiliations
Priti Tagde1 and Madan Bilawer2
Keywords
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