SOLID LIPID NANOPARTICLES: FOR ENHANCEMENT OF ORAL BIOAVAILABILITY
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2011, Vol 1, Issue 2
Abstract
Solid lipid nanoparticles are emerging as alternative carriers to colloidal systems for controlled and targeted drug delivery. SLNs combine the advantages of different colloidal carriers, like emulsions, liposome’s, (physically acceptable) polymeric nanoparticles (controlled drug release from lipid matrix) etc. Additional advantages include, lack of coalescence after reaching to room temperature, better physical stability and lack of appreciable drug leakage from the particles. In recent years much work has been focused in the development of SLNs as delivery systems for anticancer drugs, peptides, genetic material, cosmetics etc. SLNs find applications in site specific drug delivery, local action, and enhancement of bioavailability.
Authors and Affiliations
G. Kapilraj Bharat , R. Rajalakshmi , Padmaja Chimmiri
Keywords
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