IN VITRO EVALUATION OF GASTRO RETENTIVE FLOATING DRUG DELIVERY SYSTEM FOR PINDOLOL BILAYER TABLETS
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2016, Vol 6, Issue 1
Abstract
ABSTRACT Floating microspheres of Pindalol was prepared by ionic gelation method with an aim of increasing the gastric residence time and for controlled release. Sodium alginate, polymeric mixture of Sodium alginate and xanthan gum were used as polymers. Sodium bicarbonate was used as the gas-forming gent. The prepared floating microspheres were evaluated with respect to particle size distribution, floating behaviour, drug content, entrapment efficiency, morphology and in vitro release study. These results indicated that the release rate was found to decrease with increase in concentration of coating material applied. The wall thickness of microspheres was found to be increased with the increase in concentration of coating material applied. The floating microspheres followed zero order kinetics and the mechanism of drug release was governed by peppas model. For all the microspheres the exponential coefficient values were found to be in between 0.997 and 0.99988, indicating non fickian diffusion controlled release mechanism. Keywords: In vitro evaluation Pindolol, Pre formulation evaluation.
Authors and Affiliations
J. Manikanta1 *, S. Ramya Sri2 , B. Ramarao1 , G. Chiranjeevi1 , Ranjith Kumar Sura2
Keywords
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