DEVELOPMENT OF MICROBALLOONS AND IMMEDIATE RELEASE GRANULES OF PANTOPRAZOLE SODIUM FOR GASTRO RETENTIVE DRUG DELIVERY
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2013, Vol 3, Issue 1
Abstract
The intention of the present research work was to develop once daily controlled release floating microballoons of pantoprazole using different polymers like HPMC, EC and gelatin for GRDDS along with the loading dose granules with superdisintegrants. The immediate release (IR) granules were prepared by wet granulation method by using Sodium starch glycolate, Cross povidone as superdisintegrants and evaluated for the flow property and release studies. The granules showed good flowability and in vitro release of pantoprazole IR granules was found to be 96-102%. The floating microballoons were prepared by emulsion solvent diffusion method. The prepared microballoons were characterized for scanning electron microscopy (SEM), drug content, entrapment efficiency, production yield, floating ability, buoyancy percentage, in vitro drug release and release kinetics studies. The prepared microballoons were spherical and showed good flow properties. DSC studies revealed that the drug is having a very good compatibility with the polymers. SEM revealed that the microballoons had smooth surface and hollow cavity in the middle. The entrapment efficiency of microballoons was found to be 72-95 % and the drug release from the microballoons in simulated gastric fluid (SGF) was found to be 54-68 % up to 12 h. The floating ability and buoyancy percentage of the microballoons were found to be 75-88 % and it remains buoyant up to 12 h. The release kinetics study revealed that the prepared microballoons were best fitted to the zero order kinetics and indicates that the drug release obeys diffusion – controlled mechanism. Thus it conclude that GRDDS of pantoprazole (an anti-ulcer drug) loaded microballoons along with IR granules loaded capsule was an ideal drug delivery system for ulcer protective activity as both controlled and immediate release drug delivery systems.
Authors and Affiliations
N. Bhanu Priya , S. Brito Raj , G. Sravani , S. Wasim Raja , Narayana Raju
Keywords
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