DEVELOPMENT AND CHARACTERIZATION OF LOVASTATIN LOADED MICROSPHERES
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2014, Vol 4, Issue 2
Abstract
In this study, the use of biodegradable polymers for microencapsulation of Lovastatin using solvent evaporation technique was investigated. Ethyl Cellulose and Eudragit L100 was selected as a retardant polymer because of its advantages over other biodegradable polymers. Eight different batches of microspheres were prepared by varying the concentration of polymer. The microspheres were characterized for drug content, percentage yield and encapsulation efficiency, particle size analysis and surface morphology. Microsphere prepared with low drug content produces higher percentage yield and encapsulation efficiency values. It was observed the increase in concentration of the polymer, increases the mean particle size of the microspheres. The effect of polymer concentration on the in vitro release of Lovastatin from the microspheres was also studied. It can be seen that by increasing the polymer concentration, decreases the rate of drug release from the microspheres dramatically. The kinetics of drug release from F1 microspheres predominantly follows Higuchi pattern followed by zero order [3]. The release kinetics of F3 and F4 predominantly follows zero order followed by Higuchi and then first order
Authors and Affiliations
Kaur Dupinder , Saini Seema
Keywords
Related Articles
- EP ID EP163059
- DOI -
- Views 105
- Downloads 0
WATERSHED IMPACT ON AGRO-PRODUCTION AND LIVE STOCK SYSTEMS
ABSTRACT Household biomass production and processing are integral part of livelihood support systems in rain fed areas. Apart from his farm earnings the farmer leans on dairy, livestock, poultry, Piggery, househo...
INFERRING THE CHEMICAL PARAMETERS FOR THE DISSOLUTION OF FLUORIDE IN GROUNDWATER
ABSTRACT Although fluoride was once considered an essential nutrient, the U.S. National Research Council has since removed this designation due to the lack of studies showing it is essential for human growth, tho...
FORMULATION AND EVALUATION OF FLOATING MATRIX TABLETS OF RAMIPRIL USING PEANUT HUSK POWDER
improve the bioavailability of drugs. Floating drug delivery system is one of the several techniques currently used to formulate a successful gastroretentive drug delivery system. The aim of this study was to de...
FORMULATION AND EVALUATION OF BILAYER FLOATING TABLET CONTAINING VERAPAMIL HYDROCHLORIDE
The objective of the present investigation was to develop a bilayer-floating tablet (BFT) for Verapamil Hydrochloride using direct compression technology using floating and viscosity enhancing polymers such as HP...
PROCESS VALIDATION OF VALACYCLOVIR TABLETS BY OPTIMISING PROCESS PARAMETERS
In the present study, Valacyclovir tablets were formulated using different formulation parameters and their effects on the dissolution rate of these tablets were evaluated. The binding agent used in this study was...