FORMULATION AND EVALUATION OF DENTAL FILM FOR PERIODONTITIS
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2015, Vol 5, Issue 2
Abstract
ABSTRACT The study was to formulate and evaluate chitosan film containing tobramycin which will give local action for the treatment of periodontitis. Chitosan film containing tobramycin was prepared by solvent casting method. IR studies were done to determine the compatibility of drug with the polymer. Minimum inhibitory concentration of tobramycin was done by cup-plate method. The films were evaluated for their physicochemical properties like weight variation, thickness, drug content uniformity, folding endurance, % moisture loss, tensile strength and stability. Drug content uniformity was performed on Staphylococcus aureus. Scanning electron microscope (SEM) studies were done to determine the surface characteristics of the film.IR studies revealed that there is compatibility of drug with the polymer. Minimum inhibitory concentration of tobramycin was found to be 1 µg/ml. The physiochemical properties of the film showed good results. Keywords: Chitosan, Dental film, Periodontitis, Tobramycin.
Authors and Affiliations
S. C. Woo*1 , S. J Kshirsagar2 , M. R. Bhalekar1 , A. R Madgulkar1
Keywords
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