APPLICATION OF RESPONSE SURFACE METHODOLOGY FOR THE MAXIMUM PRODUCTION OF TANNASE USING ASPERGILLUS FOETIDUS (MTCC 3557)
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2014, Vol 4, Issue 3
Abstract
ABSTRACT Production of tannase by Aspergillus foetidus (MTCC 3557) using redgram husk as substrate was studied in submerged fermentation. The optimization of process parameters was carried out using Response Surface Methodology (RSM). RSM is applied for the Design Of Experiments (DOE) to evaluate the main effects, squared effects and interactive effects of the process parameters affecting the production of tannase in a submerged fermentation using Aspergillus foetidus (MTCC 3557) through a full factorial design. The optimum conditions were found to be a tannic acid concentration of 3.1 %, fermentation period of 97 h, temperature of 35.5°C and pH of 5.5 with a higher R2 value of 0.9251.The RSM revealed that a maximum tannase production of 157.6 U/ml was obtained at the optimum conditions. Keywords: Aspergillus foetidus, Response surface methodology, Submerged fermentation, Tannase.
Authors and Affiliations
Mohan S. K *1 , Viruthagiri T 2 and Arunkumar C
Keywords
Related Articles
- EP ID EP143863
- DOI -
- Views 98
- Downloads 0
RECENT TRENDS IN CONTROLLED RELEASE ORAL DRUG DELIVERY SYSTEMS: A COMPREHENSIVE REVIEW
ABSTRACT In recent decades different modern technological attempts have been explored in the research and development of controlled release oral drug delivery systems to cross the barriers of physiological advers...
“AAVARAI KUDINEER”- A POTENT POLYHERBAL SIDDHA FORMULATION FOR MANAGEMENT OF DIABETES MELLITUS
ABSTRACT Diabetes mellitus is caused due to deficiency in production of insulin. It is a global problem and number of those affected is increasing day by day. Oral hypoglycemic agents use is restricted by their p...
METFORMIN LOWERS C-REACTIVE PROTEIN LEVELS AND IMPROVES THE MODIFIED BRIEF PAIN INVENTORY SCORES IN A WOMAN WITH ENDOMETRIOSIS – ASSOCIATED CHRONIC PELVIC PAIN: A CASE REPORT AND LITERATURE REVIEW
Endometriosis is associated with low health-related quality of life and its incidence in the world is not decreasing, at least, in the developed economies. The aim of this case-report is to bring to the fore the...
FORMULATION AND EVALUATION OF OLANZAPINE FAST DISINTEGRATING TABLETS USING COPROCESSED SUPERDISINTEGRANTS
ABSTRACT Fast disintegrating tablets (FDT) have emerged as an alternative to oral conventional dosage forms to target populations like pediatric, geriatric, bedridden patients. The concept of coprocessing has bee...
STANDARDIZATION OF PROCESS PARAMETERS INVOLVED ERYTHROMYCIN MICROSPONGES BY QUASSI EMULSION SOLVENT DIFFUSION METHOD
[sub][/sub] The aim of present work is to prepare microsponges of Erythromycin using Ethyl cellulose as polymer. Erythromycin has bacteriostatic activity which inhibits growth of bacteria. They mainly act by bindin...