RECENT TRENDS IN CONTROLLED RELEASE ORAL DRUG DELIVERY SYSTEMS: A COMPREHENSIVE REVIEW
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2015, Vol 5, Issue 2
Abstract
ABSTRACT In recent decades different modern technological attempts have been explored in the research and development of controlled release oral drug delivery systems to cross the barriers of physiological adversities, like unpredictable gastric emptying times (GET) and short gastric residence times (GRT). The most successful approaches in the reigon of oral delayed release drug delivery is gastroretentive drug delivery system (GRDDS). Drugs with a narrow absorption window and having well to moderate solubility in gastric fluids are rapidly eliminated from stomach due to rapid gastric transit. GRDDS delay the retention time of dosage forms in the stomach or proximal part of gastro intestinal tract (GIT), so that it enhances solubility, ultimately bioavailability of drugs and therapeutic efficacy of the dosage form as well. Various methodologies have been adopted to enhance the gastric residence time of drugs, such as floating system, sedimentation or high density system expanding or swelling systems, bio/mucoadhesive system, hydro dynamically balanced system, geometry or modified shape system. This article aims to review the current & recent developments of gastric floating drug delivery systems to provide basic principles useful to overcome the difficulties associated with formulation design carrying wide range of drugs. Keywords: Raft forming system, Gastric emptying time, Mucoadhesive systems, Floating lag time, Hydrodynamically balanced system.
Authors and Affiliations
Soheib Afroz1 *, Naga sri ND 2 , Javeed Khan3 , Rafi B 4 , Venkaiah A4 , Manohar4 , Jameerullah4 , Hemakumar S4 , Veeranjeneyulu
Keywords
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