STANDARDIZATION OF PROCESS PARAMETERS INVOLVED ERYTHROMYCIN MICROSPONGES BY QUASSI EMULSION SOLVENT DIFFUSION METHOD
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2013, Vol 3, Issue 1
Abstract
[sub][/sub] The aim of present work is to prepare microsponges of Erythromycin using Ethyl cellulose as polymer. Erythromycin has bacteriostatic activity which inhibits growth of bacteria. They mainly act by binding to the 50s subunits of bacteria, 70s r-RNA complex, and protein synthesis. Erythromycin is also used topically to treat acne. They are used to treat moderate to severe inflammatory acnes or acne that isn’t getting better with other treatments. Erythromycin works to treat acne by reducing the amount of acne causing bacteria called “propionibacteria” acnes on the skin, it also lessens inflammation and redness. Erythromycin is easily inactivated by the gastric environment and produce gastric disturbances such as diarhoea, nausea, abdominal pain and vomiting. Erythromycin microsponges were prepared using quassi emulsion solvent diffusion method. In order to standardize the microsponge formulation, factors affecting the physical properties of microsponges were determined. The SEM and DSC studies were carried out to study shape, morphology of microsponges and thermal analysis respectively Thus it was concluded that erythromycin can be formulated as microsponge gel that can release the drug up to 8hrs with reduced side effects.
FORMULATION DEVELOPMENT AND EVALUATION OF POTASSIUM CHLORIDE EXTENDED RELEASE TABLETS
Potassium chloride is an electrolyte replenisher used in the treatment of hypokalemia. It has a short biological half-life of 1 to 1.5hours. It is a freely soluble drug in the gastric contents while taking it ora...
NOVEL APPROACH OF PHARMACEUTICAL CO-CRYSTALS FOR POORLY SOLUBLE DRUGS
Curcumin a polyphenolic active pharmaceutical ingredient, extracted from curcuma longa possess a wide variety of pharmacological activities. The utility of curcumin is limited by its, lack of water solubility, an...
FORMULATION AND EVALUATION OF MICROSPHERES ENCAPSULATING ZIDOVUDINE BY SOLVENT EVAPORATION TECHNIQUES
ABSTRACT The aim of the present study is an attempt to formulate and evaluate microspheres drug delivery of Zidovudine by using Eudragit L100 as a polymer for potentially treating HIV and AIDS related conditions....
PLANT AS A PLATFORM FOR PRODUCTION OF VACCINE
ABSTRACT Edible vaccines is a new concept for the formulation and development department in the pharmaceutical industry because it is easily available from plant, cost-effective, easy-to-administer, easy-to-store...
PHYTOCHEMICAL EVALUATION OF A MEDICINAL ORCHID: NERVILIA PLICATA (ANDREWS) SCHLTR
ABSTRACT The present study on phytochemical constituents of a medicinal orchid such as Nervilia plicata (Andrews) Schltr. reveals that, it is one of the valuable orchid with diverse medico-potentiality. More over...