Abstract

[sub][/sub]  The aim of present work is to prepare microsponges of Erythromycin using Ethyl cellulose as polymer. Erythromycin has bacteriostatic activity which inhibits growth of bacteria. They mainly act by binding to the 50s subunits of bacteria, 70s r-RNA complex, and protein synthesis. Erythromycin is also used topically to treat acne. They are used to treat moderate to severe inflammatory acnes or acne that isn’t getting better with other treatments. Erythromycin works to treat acne by reducing the amount of acne causing bacteria called “propionibacteria” acnes on the skin, it also lessens inflammation and redness. Erythromycin is easily inactivated by the gastric environment and produce gastric disturbances such as diarhoea, nausea, abdominal pain and vomiting. Erythromycin microsponges were prepared using quassi emulsion solvent diffusion method. In order to standardize the microsponge formulation, factors affecting the physical properties of microsponges were determined. The SEM and DSC studies were carried out to study shape, morphology of microsponges and thermal analysis respectively Thus it was concluded that erythromycin can be formulated as microsponge gel that can release the drug up to 8hrs with reduced side effects.

Authors and Affiliations