FORMULATION AND EVALUATION OF MICROSPHERES ENCAPSULATING ZIDOVUDINE BY SOLVENT EVAPORATION TECHNIQUES
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2015, Vol 5, Issue 1
Abstract
ABSTRACT The aim of the present study is an attempt to formulate and evaluate microspheres drug delivery of Zidovudine by using Eudragit L100 as a polymer for potentially treating HIV and AIDS related conditions. The formulation F1 to F4 which were prepared by solvent evaporation method by varying the concentration of Edragit L100 polymer ratios which were significantly affected the in vitro drug release from the prepared formulations. The in vitro drug release studies were carried out by using phosphate buffer pH 7.4. Drug and physical mixture were characterized by FTIR. The formed microspheres showed prolonged in vitro drug release. It might contribute better patient compliance while reduce frequency of dosing and by acceptable sustained-release dosage form Zidovudine microspheres promote a fast and effective against the AIDS related conditions. Keywords: Zidovudine, microspheres, HIV and AIDS related conditions, controlled drug delivery, sustained release, Edragit L100.
Authors and Affiliations
Priyadarshini M K1 *, S Parthiban1 , J. Adlin Jino Neasalin1 , A. Vikneswari2
Keywords
Related Articles
- EP ID EP101546
- DOI -
- Views 102
- Downloads 0
REVIEW ON NANOSUSPENSION TECHNOLOGY
ABSTRACT Solubility is an essential factor for drug effectiveness, independent of the route of administration. Poorly soluble drugs are often a challenging task for formulators in the industry. Large proportions...
PHOSPHOLIPON AS A BINDER IN THE FORMULATION OF 4- ACETOMIDOPHENOL TABLETS
ABSTRACT Pharmaceutical manufacturing inform of liposomal delivery has one of the most important approaches to improve the cellular uptake and subsequent bioavailability of drugs and as such phospholipon was chos...
NANOPARTICLES AS SPECIFIED CARRIERS IN TARGETED BRAIN DRUG DELIVERY SYSTEM
The blood brain barrier represents an insurmountable obstacle for a large number of drugs including antibiotics, anti neoplastics and a variety of CNS active drugs especially neuropeptides. One of the possibiliti...
DEVELOPMENT AND PARTIAL VALIDATION OF THE LAMIVUDINE DRUG IN BULK AND SOLID DOSAGE FORM BY UV-SPECTROSCOPY
Abstract A new, simple and sensitive spectrophotometric method in ultraviolet region has been developed for the determination of Lamivudine in bulk and in pharmaceutical formulations. Lamivudine exhibits absorp...
A REVIEW ON NANOTECHNOLOGY IN SOLID LIPID NANOPARTICLES
This present review is progress in selected nanotechnology topics and some possible applications. This attempt mainly focused on solid lipid nanoparticles & different preparation methods of solid lipid nanopa...