NANOPARTICLES AS SPECIFIED CARRIERS IN TARGETED BRAIN DRUG DELIVERY SYSTEM
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2013, Vol 3, Issue 1
Abstract
The blood brain barrier represents an insurmountable obstacle for a large number of drugs including antibiotics, anti neoplastics and a variety of CNS active drugs especially neuropeptides. One of the possibilities to overcome this barrier is a drug delivery to brain using nanoparticles. The use of nanoparticles to deliver drugs to the brain across the blood brain barrier may provide a significant advantage to current strategies. The primary advantage of nanoparticles carrier technology is that nanoparticles mask the blood brain barrier limiting the characteristics of the therapeutics, drug molecules and it also decreasing peripheral toxicity by causing slow drug release in the brain. The nanoparticles may be especially helpful for the treatment of the disseminated and very aggressive brain tumors. The mechanism of nanopraticles mediated transport of drugs is mostly endocytosis by endothelial cells lining the brain blood capillaries.
Authors and Affiliations
Shivaraju , GK Avinash , S Parthiban , SK Senthilkumar
Keywords
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