FORMULATION AND EVALUATION OF FLOATING MATRIX TABLETS OF RAMIPRIL USING PEANUT HUSK POWDER
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2013, Vol 3, Issue 2
Abstract
improve the bioavailability of drugs. Floating drug delivery system is one of the several techniques currently used to formulate a successful gastroretentive drug delivery system. The aim of this study was to develop non effervescent floating matrix tablets of ramipril using peanut husk powder. Formulations were prepared by direct compression method and evaluated for buoyancy behavior, drug content, and in vitro drug release. Use of HPMC K100M in the formulations enhanced the floating duration and dimensional stability. The optimized formulation followed Higuchi kinetics. It can be concluded that peanut husk powder can be a promising low density material in the formulation of gastroretentive floating drug delivery systems in combination with synthetic polymer HPMC K100M.
Authors and Affiliations
Chandra Sekhara Rao G , Ramadevi K , Soujanya V , Prasad Ch
Keywords
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