REVIEW ON NANOSUSPENSION TECHNOLOGY
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2015, Vol 5, Issue 2
Abstract
ABSTRACT Solubility is an essential factor for drug effectiveness, independent of the route of administration. Poorly soluble drugs are often a challenging task for formulators in the industry. Large proportions of newly discovered drugs are water insoluble, and therefore poorly bioavailable contributing to deserted development effort. Nanosuspension technology solved the problem of drugs which are poorly aqueous soluble and less bioavailability. Stability and bioavailability of the drugs can be improved by the Nanosuspension technology. Preparation of Nanosuspension is Simple and applicable to all drugs which are insoluble in water. Nanosuspensions are prepared by using wet mill, high pressure homogenizer, emulsion‐solvent evaporation, melt emulsification method and super critical fluid techniques. Nanosuspensions can be delivered by oral, Parenteral, pulmonary and ocular routes. Nanosuspensions can also be used for targeted drug delivery when incorporated in the ocular inserts and mucoadhesive hydro gels. Keywords: Nanosuspension, Solubility enhancement, Bioavailability.
Authors and Affiliations
Devasani Anusha*, V. Uma Maheshwar Rao & S. Raja shekhar
Keywords
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