DESIGN AND EVALUATION OF GELATIN MICROSPHERES CONTAINING DICLOFENAC SODIUM
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2012, Vol 1, Issue 1
Abstract
Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers which are biodegradable in nature and ideally having a particle size less than 200 μm. The present study is aimed to formulate the Diclofenac Sodium (DFS) microspheres by using Co-acervation phase separation procedure to get better bioavailability of drug. In this study, we used DFS as a drug of choice since it has biological half-life of about 1-2 hrs. DFS microspheres were formulated by using different drug, gelatin and HPMC ratios. A total of 5 batches was F1, F2, F3, F4, F5 & F6 of varying concentrations of drug, gelatin and HPMC were prepared. DFS microspheres were evaluated by various tests like particle size analysis, angle of repose and bulk density. Further DFS Micro spheres were examined for in-vitro dissolution, by using phosphate buffer (PH 7.4) to make out the release of the drug
Authors and Affiliations
Umamahesh B , Lavanya N , Kusuma P Kumar , SR Guggilla2
Keywords
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