PHOSPHOLIPON AS A BINDER IN THE FORMULATION OF 4-ACETOMIDOPHENOL TABLETS
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2016, Vol 6, Issue 2
Abstract
ABSTRACT Pharmaceutical manufacturing inform of liposomal delivery has one of the most important approaches to improve the cellular uptake and subsequent bioavailability of drugs and as such phospholipon was chosen as a binder and studied for its effectiveness by comparing with microcrystalline cellulose and corn starch using wet granulation method. Wet granulation method using phospholipon, corn starch and microcrystalline cellulose as a binder was employed. The compressed tablets were evaluated for the following physicochemical characteristics; general appearance, weight variation, friability, hardness, disintegration and in vitro drug release studies. The release pattern of 1% dispersion of phospholipon in water has met the USP specification, in which more than 80 % of paracetamol tablet was released at 30 minutes. The release pattern of the drug was observed to be time dependent at the duration of time used. In addition, the amount of drug released by phospholipon and corn starch at 60 minutes interval was greater than 100%. The tablets obtained in this study have an approximate average weight which is within the limit of the percentage deviation allowed by USP. The tablets showed a slight variation in diameter and thickness which is within the BP limits and hence negligible. In the present study, the observed hardness for phospholipon and MCC were within the USP specification (4 to 8 kgF), whereas for corn starch, the value were above the USP specification. The percentage friability of the MCC was similar to that of the phospholipon, whereas for corn starch, the value was lower. The disintegration time of phospholipon was found to be higher than the two formulations. The binding capacity of phospholipon at low concentration for drug delivery especially in the formulation of paracetamol tablets was assessed and found to be better than microcrystalline cellulose and corn starch. This amply justifies the current use of phospholipon as a binder in many pharmaceutical formulations. Keywords: Phospholipon, 4-acetomidophenol, Binder, Tablet.
Authors and Affiliations
Galadima HI1* , Mbah CC1 , Emenike IV2 , Moh’d AS3 , Timothy SY4
Keywords
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