DEVELOPMENT AND PARTIAL VALIDATION OF THE LAMIVUDINE DRUG IN BULK AND SOLID DOSAGE FORM BY UV-SPECTROSCOPY
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2012, Vol 1, Issue 1
Abstract
Abstract A new, simple and sensitive spectrophotometric method in ultraviolet region has been developed for the determination of Lamivudine in bulk and in pharmaceutical formulations. Lamivudine exhibits absorption maxima at 270 nm. Developed method obeyed the Beer’s law in the concentration range of 5 - 25 μg/mL. The method is accurate, precise and economical. The proposed method has been applied successfully for the analysis of the drug in pure and in its tablet dosage forms. In this method, there is no interference from any common pharmaceutical additives and diluents. The % recovery is greater than 98 to101%. %, this shows that the method was free from the interference of excepients. The results of the tablet analysis were validated with respect to accuracy (recovery), linearity, limit of detection and limit of quantization were found to be satisfactory.
Authors and Affiliations
P. V. Rajesh, , C. P. Karunasree, , G. Dharmamoorthy , K. Padmini , CH. Sudeer
Keywords
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DEVELOPMENT AND PARTIAL VALIDATION OF THE LAMIVUDINE DRUG IN BULK AND SOLID DOSAGE FORM BY UV-SPECTROSCOPY
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