REVIEW ON NATURAL PUMPS: A NOVEL DRUG DELIVERY SYSTEM
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2013, Vol 3, Issue 2
Abstract
Pharmaceutical invention and research are increasingly focusing on delivery systems which enhance desirable therapeutic objectives while minimizing the side effects. The conventional dosage forms have less control on the drug release and no control over the effective concentration at the target site. This dosing pattern mostly results in constantly changing, unpredictable plasma concentrations. By the process of osmosis one can deliver the drug in a controlled manner over a long period of time. Osmotic drug delivery systems are most promising systems for controlled drug delivery. These Osmotic devices can be used orally or as implants for the delivery of the active agents. The release of the drugs from the osmotic systems is affected by various formulation factors such as osmotic pressure and solubility of the core component, size of the delivery orifice and nature of the rate controlling membrane. By the optimization of the formulation and processing factors, it is possible to develop osmotic devices to deliver the drugs at a pre-programmed rate mostly zero order release. In present review the focus is on the basic principles of osmosis, history of osmotic pumps, Formulation aspects and Types of osmotic systems with examples and illustrative figures.
Authors and Affiliations
Mohammad Ali , S K Senthilkumar , S Parthiban
Keywords
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