FORMULATION AND IN-VITRO CHARACTERIZATION OF FLOATING MICROCARRIERS OF VENLAFAXINE HYDROCHLORIDE
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2012, Vol 1, Issue 2
Abstract
The objective of the present study was to develop multiparticulate gastro retentive drug delivery system of Venlafaxine hydrochloride by Emulsion gelation method using sodium alginate as a polymer and liquid paraffin. Floating microcarriers of the Venlafaxine hydrochloride was developed to prolong the gastric residence time, increase therapeutic efficiency, reduce frequency of administration and improve patient compliance. The prepared microcarriers were evaluated for micrometric properties, particle size, % drug entrapment efficiency, buoyancy percentage, in vitro-drug release studies. The prepared microcarriers were free flowing and discrete. The %drug entrapment was found in the range of 46.93 to 71.88. F1 formulation showed highest entrapment efficiency (71.88). There was no lag time was observed, the microcarriers immediately floated and remained floating for more than 10 hours. The particle size of the floating microcarriers was in the range of 0.54-1.26 mm. the drug release was studied up to 7 hours and results indicates that F6 formulation was found to be best suitable one.
Authors and Affiliations
Shaik Firoz, , M. Dhanunjaya Naik , S. Mohammed Rafi , N. Renuka Yella Reddy , S. Santhosh Kumar , A. Vikram
Keywords
Related Articles
- EP ID EP131984
- DOI -
- Views 99
- Downloads 0
ONE STEP DRY COATED TABLETS (OSDRC) - A REVIEW
Drug delivery has metamorphosed from the concept of pill to molecular medicine in the past 100 years. Better appreciation and integration of pharmacokinetic and pharmacodynamic principles in the design of drug de...
NANOHYDROGEL DRUG DELIVERY: A REVIEW
ABSTRACT Hydrogels are hydrophilic, three-dimensional networks, which are able to imbibe large amounts of water or biological fluids, and thus resemble, to a large extent, a biological tissue. They are insoluble...
CHROMATOGRAPHIC STUDIES OF MULTICOMPONENT VAGINAL SUPPOSITORY
ABSTRACT The article presents the results of quantitative research and identification of active- pharmaceutical ingredients (APIs ) vaginal suppository. To conduct the study using high performance liquid chromato...
FORMULATION AND EVALUATION OF DENTAL FILM FOR PERIODONTITIS
ABSTRACT The study was to formulate and evaluate chitosan film containing tobramycin which will give local action for the treatment of periodontitis. Chitosan film containing tobramycin was prepared by solvent ca...
PLANT AS A PLATFORM FOR PRODUCTION OF VACCINE
ABSTRACT Edible vaccines is a new concept for the formulation and development department in the pharmaceutical industry because it is easily available from plant, cost-effective, easy-to-administer, easy-to-store...