FORMULATION AND IN-VITRO CHARACTERIZATION OF FLOATING MICROCARRIERS OF VENLAFAXINE HYDROCHLORIDE
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2012, Vol 1, Issue 2
Abstract
The objective of the present study was to develop multiparticulate gastro retentive drug delivery system of Venlafaxine hydrochloride by Emulsion gelation method using sodium alginate as a polymer and liquid paraffin. Floating microcarriers of the Venlafaxine hydrochloride was developed to prolong the gastric residence time, increase therapeutic efficiency, reduce frequency of administration and improve patient compliance. The prepared microcarriers were evaluated for micrometric properties, particle size, % drug entrapment efficiency, buoyancy percentage, in vitro-drug release studies. The prepared microcarriers were free flowing and discrete. The %drug entrapment was found in the range of 46.93 to 71.88. F1 formulation showed highest entrapment efficiency (71.88). There was no lag time was observed, the microcarriers immediately floated and remained floating for more than 10 hours. The particle size of the floating microcarriers was in the range of 0.54-1.26 mm. the drug release was studied up to 7 hours and results indicates that F6 formulation was found to be best suitable one.
Authors and Affiliations
Shaik Firoz, , M. Dhanunjaya Naik , S. Mohammed Rafi , N. Renuka Yella Reddy , S. Santhosh Kumar , A. Vikram
Keywords
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