IN VITRO PERMEATION AND PHARMACO-DYNAMIC PROPERTIES OF GEL FORMULATIONS CONTAINING FLUOCINONIDE ENTRAPPED NIOSOMES
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2014, Vol 4, Issue 1
Abstract
Niosomes are now widely studied as an alternative to liposomes because they alleviate the disadvantages of liposomes, such as chemical instability, variable purity of phospholipids and high cost. The aim of this work is to formulate and evaluate niosomes as carriers for topical delivery of Fluocinonide, as an anti-inflammatory drug, test their stability and improve their anti-inflammatory effect through niosomal encapsulation with objectives of prolonging its action and avoiding its most side effects. Incorporation of Fluocinonide – entrapped niosomes into gelling agents and increasing their concentrations resulted in a marked decrease in amount of drug permeated from the gel through cellulose membrane and rabbit skin. Polymers used as gelling agents are Carbopol 934 and Carboxy Methyl Cellulose sodium (CMC Na). It was found that permeated amount of Fluocinonide decreased with increasing either concentration of Carbopol 934 from 1% to 2% or concentration of CMC Na from 2% to 4%. Amount of Fluocinonide permeated from cellulose membrane are significantly high compared to the amounts permeated across the skin (p<0.01) from the same formulation. On the other hand, there is an increase in the amount of drug permeated from niosomal gels through rabbit skin, compared to that permeated from control drug gels prepared from the same gelling agents (enhancement effect). Stability study was carried out to detect effect of temperature on leakage of drug from the niosomal vesicles and evaluate the percentage of drug retained in the niosomal vesicles and niosomal gel formulations, respectively at different storage temperature (4 ° C, 25 °C and 37 °C). The data obtained were compared statistically using one-way analysis of variance (ANOVA), using Tukey-Krammer Multiple Comparison Test. The anti-inflammatory activity (pharmaco-dynamic properties) of Fluocinonide in its selected formulae was studied using the rat hind paw edema technique and compared with control untreated group. Niosomal gel formula, (F13), containing Span 40: Tween 40: Cholesterol in ratios of 25: 25: 50, consequently and 3% CMC Na is proved to be the most stable and efficient formula for anti - inflammatory activity.
Authors and Affiliations
Bindu Reddy S , Ravindra Reddy K
Keywords
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