FENOTEROL BETA- AGONIST ON CONTRACTION AND RELAXATION OF INTESTINAL SMOOTH MUSCLE OF MALE ALBINO BALB-C MICE
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2014, Vol 4, Issue 1
Abstract
The gastrointestinal tract is responsible for the absorption of nutrients and water into the body as well as the elimination of body waste. The small intestine is comprised of a long convoluted tube that is divided into the duodenum, jejunum, and ileum. Its functions consist of absorption of nutrients and water as well as retention and passage of waste materials. The movement of intestinal contents is dependent on the contraction of muscle fibers that are located throughout the intestinal wall. Absorption and movement of the contents are brought about by the activities of the absorptive cells of the mucosa and by coordinated contraction of the smooth muscle cells of the muscularis externa. The movements of the gut involve simultaneous contractions and relaxations of both circular and longitudinal smooth muscle layers at every point along its length. Mechanical recordings of physiological events can be traced back to the kymographic method. Keeping the above findings in view, the present study aims at understanding, whether already established dose of fenoterol, known to induce atrophic changes in muscles is likely to induce any toxic effects on other organ of vital importance or not. Hence, the experiment is designed in such a way to examine the undesirable toxic effects on smooth muscles.
Authors and Affiliations
Pooja Sharma , Sushma Sharma
Keywords
Related Articles
- EP ID EP131991
- DOI -
- Views 91
- Downloads 0
NOVEL APPROACH OF PHARMACEUTICAL CO-CRYSTALS FOR POORLY SOLUBLE DRUGS
Curcumin a polyphenolic active pharmaceutical ingredient, extracted from curcuma longa possess a wide variety of pharmacological activities. The utility of curcumin is limited by its, lack of water solubility, an...
STUDY ON ALKALOID ESTIMATION BY HPLC IN WITHANIA SOMNIFERA (LINN) DUNAL WITH REFERENCE TO TREATMENT WITH GROWTH REGULATORS
ABSTRACT Many medicinal plants are used in modern medicine where they occupy a very significant place as raw material for important drugs and plants used in traditional system of medicine in pharmaceutical houses...
ENHANCEMENT SOLUBILITY AND DISSOLUTION OF MEFENAMIC ACID BY MODIFIED STARCH
The objective of the present research work is to enhance the dissolution profile of the mefenamic acid by Modified Starch as a carrier. Starch citrate was prepared by reacting the citric acid with starch at elevate...
DESIGN AND IN VIVO EVALUATION OF GASTROINTESTINAL MUCOADHESIVE PATCH SYSTEM (GMPS) LOADED WITH CHITOSAN NANOPARTICLES
ABSTRACT A novel gastrointestinal mucoadhesive patch system was designed to improve the oral bioavailability of macromolecular therapeutics using chitosan nanoparticles for effective delivery of macromolecules (u...
A REVIEW ON GENE SILENCING
ABSTRACT Gene silencing is a epigenetic term which means the expression of a particular gene is reduced by genetic engineering techniques using mechanism like DNA methylation and RNA interference. This technique...