FENOTEROL BETA- AGONIST ON CONTRACTION AND RELAXATION OF INTESTINAL SMOOTH MUSCLE OF MALE ALBINO BALB-C MICE
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2014, Vol 4, Issue 1
Abstract
The gastrointestinal tract is responsible for the absorption of nutrients and water into the body as well as the elimination of body waste. The small intestine is comprised of a long convoluted tube that is divided into the duodenum, jejunum, and ileum. Its functions consist of absorption of nutrients and water as well as retention and passage of waste materials. The movement of intestinal contents is dependent on the contraction of muscle fibers that are located throughout the intestinal wall. Absorption and movement of the contents are brought about by the activities of the absorptive cells of the mucosa and by coordinated contraction of the smooth muscle cells of the muscularis externa. The movements of the gut involve simultaneous contractions and relaxations of both circular and longitudinal smooth muscle layers at every point along its length. Mechanical recordings of physiological events can be traced back to the kymographic method. Keeping the above findings in view, the present study aims at understanding, whether already established dose of fenoterol, known to induce atrophic changes in muscles is likely to induce any toxic effects on other organ of vital importance or not. Hence, the experiment is designed in such a way to examine the undesirable toxic effects on smooth muscles.
Authors and Affiliations
Pooja Sharma , Sushma Sharma
Keywords
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