ENHANCEMENT SOLUBILITY AND DISSOLUTION OF MEFENAMIC ACID BY MODIFIED STARCH
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2012, Vol 1, Issue 2
Abstract
The objective of the present research work is to enhance the dissolution profile of the mefenamic acid by Modified Starch as a carrier. Starch citrate was prepared by reacting the citric acid with starch at elevated temperature. Starch citrate was exhibited good flow properties and it had good swelling property without pasting when heated in water was consider to be promising carrier for solid dispersions for enhancing the dissolution rate of poorly water soluble drugs. Starch citrate was characterized by Fourier transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) and these results were suggesting that structure of starch had been modified. Mefenamic acid is a non-steroidal anti-inflammatory drug belongs to the Biopharmaceutics classification system (BCS) class II drug. Dissolution rate is the rate determining step in the bioavailability of the mefenamic acid. Dissolution profile of the mefenamic acid was improved by solid dispersion technique. Solid dispersions were prepared by solvent evaporation method. Prepared solid dispersions were characterized by Fourier transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC) and Scanning electron microscopy (SEM). In vitro dissolution studies were carried by using USP (XXIV) type II apparatus. Results of the Fourier transform infrared spectroscopy and Differential scanning calorimetry were revealed that there were no interactions between the drug and polymer. Mean dissolution rate of the pure drug was improved from 0.6391to 4.740. A 4.740 fold improvement in the mean dissolution rate of mefenamic acid was observed. Initial dissolution rate and dissolution efficiency of mefenamic acid were also found to improved. It was concluded that Starch citrate is promising carrier for dissolution enhancement of poorly water soluble drugs.
Authors and Affiliations
Amaravathi Vikram , S Firoz , Y Chandra mouli , T Venkataramudu1
Keywords
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- EP ID EP163051
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