FORMULATION AND EVALUATION OF EXTENDED RELEASE TABLET OF DIVALPROEX SODIUM USING DIFFERENT POLYMERS AS RELEASE RETARDING AGENT
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2014, Vol 4, Issue 3
Abstract
ABSTRACT The main objective of this work is to investigate the possibility of sustained release dosage forms for the drug Divalproex Sodium by using different polymers like Hydroxy Propyl methyl cellulose, Hydroxy Propyl cellulose by the diffusion controlled matrix. Various formulations of extended release tablets of Divalproex Sodium were developed using various polymers viz, HPC-HF, HPMC K4M, HPMC K15M and HPMC K100M in different proportions and combinations by direct compression technique. The tablets were evaluated for physical characterization, in vitro release study and stability studies. Results of in vitro release profile indicated that formulation (DERT-V) was the most promising formulation as the extent of drug release from this formulation was optimum and match with the In-house Specification when compared to other formulations. The formulation of extended release tablet of Batch DERT-V containing 19.5% of HPMC K100M and 7% of HPMC K4M can be taken as an ideal or optimized formulation of extended release tablets for 18 hour release as it fulfills all the requirements for extended release tablet. Keywords: Direct compression, Divalproex Sodium, Hydroxy propyl methylcellulose, In-vitro release studies.
Authors and Affiliations
B. S. Shibu1 *, S. Suresh1 , C. Saravanan
Keywords
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