FORMULATION AND IN VITRO EVALUATION OF MEXILETINE HYDROCHLORIDE TIMED RELEASE CAPSULES
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2016, Vol 6, Issue 1
Abstract
ABSTRACT The aim of the present work was formulation and in-vitro evaluation of Mexiletine hydrochloride 200mg timed- release capsules. Which release the drug at different time intervals in the GI tract. Objective of the work is to formulate timed release dosage form by adopting wet granulation method using synthetic polymers (HPMCE15), Croscormellose sodium and Eudragit L 100 at different ratios. Timed-release capsules of Mexiletine HC1 were successfully prepared using Lactose, HPMC E15 and Eudragit L 100 by wet granulation method. The timed-release capsules were evaluated for pharmacopoeial and nonPharmacopoeial tests. Based on the results batch F4 was identified as better formulations amongst all formulations for delivering the drug in a pulsatile manner. Mexiletine HC1 release from the developed formulations has been observed to be directly proportional to the amount of polymer present in capsules. Capsules of batch F4 passed all official and unofficial quality control tests. Data obtained from kinetic treatment revealed F4 formulation follow Higuchi model. Accelerated stability developed formulations were found to be stable. Keywords: Mexiletine hydrochloride, Evaluation, Formulation.
Authors and Affiliations
K. K. Senthil Kumar1*, K. G. Parthiban2 , B. Chandrasekaran3
Keywords
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