TABLETING PROPERTIES OF THERMALLY ACTIVATED COW BONE POWDER IN HIGH DOSE FORMULATION

Abstract

 ABSTRACT Activated cow bone powder was evaluated and found suitable as a diluent in the formulation of low and high dose drugs. This study was conducted in order to compare the diluent properties of dicalcium phosphate (DCP) and activated bone powder (ABP) in the formulation of high dose drugs. The mixed powders were pelletized with the specac pelletization machine, using a compaction force between 10-20 metric tonnes. A sample weight of 666 mg of the granules was used to calibrate the volumetric fill of the die using 12.5 mm punch and die set. The appropriate compression force which varied from 10-20 metric tonnes was applied to compress the granules into tablets. The formulated metronidazole tablet was evaluated for properties such as weight uniformity, thickness, crushing strength, friability, disintegration and organoplastic. Compressibility of the pellets increased with decrease in particle size fractions, and the ABP compressibility was found to be higher than that of DCP. The crushing strength of compacts formed, decreased with increase in initial particle size fraction. The disintegration times were within the acceptable time limit. The hardness of the tablets containing same formulation with ABP compared with DCP was higher in all cases. The friability values of formulations I and II of the tablets ranged between 0.4 to 0.8%, all within the value of not more than 1% standard, normally fixed by most tablet manufacturing industries. The tablet weight variations of <2% showed that the weights of the tablets were uniform. Activated cow bone powder was found to be better direct compressible diluents than the commercially available dicalcium phosphate for high dose drugs such as metronidazole. Keywords: Formulation, Metronidazole, Activated bone powder.

Authors and Affiliations

Emenike IV1* , Timothy SY2 , Okpanachi GO1 , Musa H3

Keywords

Related Articles

 THE BIONIC EYE

 ABSTRACT Aim of bionic eye is to restore vision to patients who have gone blind due to macular degeneration or retinitis pigmentosa. In the past 20 years, biotechnology has become the fastest-growing area of scie...

 USE OF INORGANIC CHEMICAL & ITS IMPACT ON HUMAN HEALTH: A CASE OF FARMERS IN INDIA

 ABSTRACT There was a time when every scientific research had a large importance in society but ignoring its side effects. So some those type of invention are widely accepted which are not eco-friendly. The conven...

 RAPID POLYMERASE CHAIN REACTION METHOD FOR DETECTION OF VIBRIO CHOLERAE IN FOOD AND THEIR CYTOTOXIC EFFECT

 In the present study, the rapid detection of Vibrio cholerae in food and cytotoxic activity, food samples were collected. Twelve food samples were analyzed for the incidence of Vibrio cholera. The organism isolat...

FORMULATION AND IN-VITRO CHARACTERIZATION OF FLOATING MICROCARRIERS OF VENLAFAXINE HYDROCHLORIDE

 The objective of the present study was to develop multiparticulate gastro retentive drug delivery system of Venlafaxine hydrochloride by Emulsion gelation method using sodium alginate as a polymer and liquid para...

 FORMULATION AND EVALUATION OF MICROSPHERES ENCAPSULATING ZIDOVUDINE BY SOLVENT EVAPORATION TECHNIQUES

 ABSTRACT The aim of the present study is an attempt to formulate and evaluate microspheres drug delivery of Zidovudine by using Eudragit L100 as a polymer for potentially treating HIV and AIDS related conditions....

Download PDF file
  • EP ID EP101549
  • DOI -
  • Views 110
  • Downloads 0

How To Cite

Emenike IV1*, Timothy SY2, Okpanachi GO1, Musa H3 (2016).  TABLETING PROPERTIES OF THERMALLY ACTIVATED COW BONE POWDER IN HIGH DOSE FORMULATION. International Journal of Pharmaceutical Development & Technology, 6(2), 65-70. https://europub.co.uk/articles/-A-101549