TABLETING PROPERTIES OF THERMALLY ACTIVATED COW BONE POWDER IN HIGH DOSE FORMULATION
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2016, Vol 6, Issue 2
Abstract
ABSTRACT Activated cow bone powder was evaluated and found suitable as a diluent in the formulation of low and high dose drugs. This study was conducted in order to compare the diluent properties of dicalcium phosphate (DCP) and activated bone powder (ABP) in the formulation of high dose drugs. The mixed powders were pelletized with the specac pelletization machine, using a compaction force between 10-20 metric tonnes. A sample weight of 666 mg of the granules was used to calibrate the volumetric fill of the die using 12.5 mm punch and die set. The appropriate compression force which varied from 10-20 metric tonnes was applied to compress the granules into tablets. The formulated metronidazole tablet was evaluated for properties such as weight uniformity, thickness, crushing strength, friability, disintegration and organoplastic. Compressibility of the pellets increased with decrease in particle size fractions, and the ABP compressibility was found to be higher than that of DCP. The crushing strength of compacts formed, decreased with increase in initial particle size fraction. The disintegration times were within the acceptable time limit. The hardness of the tablets containing same formulation with ABP compared with DCP was higher in all cases. The friability values of formulations I and II of the tablets ranged between 0.4 to 0.8%, all within the value of not more than 1% standard, normally fixed by most tablet manufacturing industries. The tablet weight variations of <2% showed that the weights of the tablets were uniform. Activated cow bone powder was found to be better direct compressible diluents than the commercially available dicalcium phosphate for high dose drugs such as metronidazole. Keywords: Formulation, Metronidazole, Activated bone powder.
Authors and Affiliations
Emenike IV1* , Timothy SY2 , Okpanachi GO1 , Musa H3
Keywords
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