DESIGN AND IN VIVO EVALUATION OF GASTROINTESTINAL MUCOADHESIVE PATCH SYSTEM (GMPS) LOADED WITH CHITOSAN NANOPARTICLES
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2014, Vol 4, Issue 4
Abstract
ABSTRACT A novel gastrointestinal mucoadhesive patch system was designed to improve the oral bioavailability of macromolecular therapeutics using chitosan nanoparticles for effective delivery of macromolecules (using FITC-Dextran as model drug). The patch system consisted of mucoadhesive layer containing the drug and backing layer made of water-impermeable polymer. The gastrointestinal mucoadhesive patch (GMP) was formulated using 10% ethyl cellulose in 80:20 dichloromethane:methanol along with triethyl citrate as plasticizer. The mucoadhesive layer was formulated using 2% carbopol dispersion in water along with 30% propylene glycol as a plasticizer. Pharmacokinetic study was done in rabbits for FITC-Dextran solution, patch containing FITCDextran incorporated in to the mucoadhesive layer filled into enteric coated capsules and patch containing FITC-Dextran incorporated chitosan nanoparticles loaded in to the mucoadhesive layer filled inside enteric coated capsules. FITC-Dextran was found to be 1.16 times more bioavailable orally from chitosan nanoparticle loaded in mucoadhesive layer as compared to other prepared formulations. Keywords: Patch system, FITC-Dextran, Chitosan nanoparticles, Mucoadhesion, Gastrointestinal, Pharmacokinetics.
Authors and Affiliations
Samir Kalavadia1 , Ranjeet Prasad Dash2 , Manju Misra1 , Manish Nivsarkar2,*
Keywords
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