DESIGN AND IN VIVO EVALUATION OF GASTROINTESTINAL MUCOADHESIVE PATCH SYSTEM (GMPS) LOADED WITH CHITOSAN NANOPARTICLES

Abstract

 ABSTRACT A novel gastrointestinal mucoadhesive patch system was designed to improve the oral bioavailability of macromolecular therapeutics using chitosan nanoparticles for effective delivery of macromolecules (using FITC-Dextran as model drug). The patch system consisted of mucoadhesive layer containing the drug and backing layer made of water-impermeable polymer. The gastrointestinal mucoadhesive patch (GMP) was formulated using 10% ethyl cellulose in 80:20 dichloromethane:methanol along with triethyl citrate as plasticizer. The mucoadhesive layer was formulated using 2% carbopol dispersion in water along with 30% propylene glycol as a plasticizer. Pharmacokinetic study was done in rabbits for FITC-Dextran solution, patch containing FITCDextran incorporated in to the mucoadhesive layer filled into enteric coated capsules and patch containing FITC-Dextran incorporated chitosan nanoparticles loaded in to the mucoadhesive layer filled inside enteric coated capsules. FITC-Dextran was found to be 1.16 times more bioavailable orally from chitosan nanoparticle loaded in mucoadhesive layer as compared to other prepared formulations. Keywords: Patch system, FITC-Dextran, Chitosan nanoparticles, Mucoadhesion, Gastrointestinal, Pharmacokinetics.

Authors and Affiliations

Samir Kalavadia1 , Ranjeet Prasad Dash2 , Manju Misra1 , Manish Nivsarkar2,*

Keywords

Related Articles

 BIODEGRADABLE POLYMER MICRONEEDLES FOR CONTROLLED-RELEASE DRUG DELIVERY

 Biopharmaceuticals, which include proteins, DNA, vaccines and other biologically related molecules, make up one of the fastest growing segments of the overall pharmaceutical market. However, there are significant d...

 PROTECTION AGAINST ENDOTHELIAL DYSFUNCTION BY PIOGLITAZONE AND IRBESARTAN IN FRUCTOSE-FED DIABETIC RATS

 ABSTRACT The protective effects of metformin, pioglitazone, irbesartan, ramipril; and their combinations against oxidative stress and endothelial dysfunction in the aortic tissues in type-2 diabetic rats were inv...

 PLANT-MEDIATED SILVER NANOPARTICLES USING Semecarpus anacardium LINN AND BIOLOGICAL EVALUATION OF TOXICOLOGY STUDIES IN ANTI-MUTAGENICITY

 ABSTRACT Semecarpus anacardium a common medicinal plant, has multiple uses in traditional system of medicine and in particular it is used as a Vermifuge for centuries. The plant and its extracts have been evaluat...

 FLOATING DRUG DELIVERY SYSTEMS: A NOVEL APPROACH

 During the past few decades, numerous oral drug delivery systems have been developed to act as drug reservoirs from which the active substance can be released over a specific period of time at a predetermined and...

 A REVIEW ON RECOMBINANT DNA TECHNOLOGY

 Recombinant DNA is artificially created from two or more DNA incorporated into a single molecule. Genetic engineering, recombinant DNA technology, genetic modification/manipulation and gene splicing are terms tha...

Download PDF file
  • EP ID EP123152
  • DOI -
  • Views 63
  • Downloads 0

How To Cite

Samir Kalavadia1, Ranjeet Prasad Dash2, Manju Misra1, Manish Nivsarkar2, * (2014).  DESIGN AND IN VIVO EVALUATION OF GASTROINTESTINAL MUCOADHESIVE PATCH SYSTEM (GMPS) LOADED WITH CHITOSAN NANOPARTICLES. International Journal of Pharmaceutical Development & Technology, 4(4), 258-266. https://europub.co.uk/articles/-A-123152