IN-VITRO ANTI INFLAMMATORY ACTIVITY OF ULTRA SONIC BATH ASSISTED, METHANOL EXTRACT OF LEPIDIUM SATIVUM LINN. SEEDS
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2013, Vol 3, Issue 2
Abstract
Plants can provide biologically active molecules and lead structures for the development of modified derivatives with enhanced activity and reduced toxicity. There are certain problems associated with use of animals in experimental pharmacological research such as ethical issues and the lack of rationale for their use when other suitable methods are available or could be investigated. Hence, in the present study the protein denaturation bioassay was selected for in vitro assessment of anti-inflammatory property of methanol extract of Lepidium sativum seeds. Denaturation of tissue proteins is one of the well documented causes of inflammatory and arthritis diseases. Production of auto antigens in certain arthritic diseases may be due to denaturation of tissue proteins in vivo. Anti-inflammatory agent that can prevent protein denaturation. Therefore, would be worthwhile for anti-inflammatory drug development.
Authors and Affiliations
Sowjanya Kumar Reddy R , Vishweswar Rao V , Bushra Fathima , Kapila M, , Srilakshmi M
Keywords
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