FORMULATION AND EVALUATION OF MEFENAMIC ACID EXTENDED RELEASE LIQUISOLID TABLETS
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2013, Vol 3, Issue 2
Abstract
Liquisolid system refers to formulations formed by conversion of liquid drugs, drug suspension or drug solution in non-volatile solvents in to non-adherent, free flowing and compressible powder mixtures by blending the solution or suspension with selected carriers and coating materials. The aim of the present work was to formulate and evaluate extended release liquisolid compacts of Mefenamic acid. Liquisolid extended release formulations were prepared by using HPMC K100M as adjuvant for extended release. Different liquisolid compacts were prepared using a mathematical model to calculate the required quantities of powder and liquid ingredients to produce acceptable and free flowing compressible mixtures. Avicel PH 102, Aerosil-200 were employed as carrier and coating materials. The prepared liquisolid compacts were evaluated for their flow properties such as bulk density, tapped density, angle of repose, Carr’s compressibility index, Hausner’s ratio. Drug-excipients interactions were studied by FT-IR. Drug release rates of liquisolid compacts shows significant benefit and distinct drug release profiles when compared to normal extended release tablets and from the results it was concluded that at higher amount of Aerosil 200 (Batch F12), drug release was found to be retarded as compared to other batches. Increase in concentration of HPMC K100M might be responsible to get extended effect. The obtained drug release data of liquisolid compacts were fitted into several mathematical models such as Zero order, First order, Higuchi, Korsemayer-Peppas, and the obtained data was fitted into zero order release pattern followed by non-fickian transport mechanism. Drug release profiles on model fitting follow Peppas model as best fit model which indicates drug diffusion in hydrated matrix and polymer relaxation
Authors and Affiliations
CH. Pradeep Kumar , P. Venugopalaiah , CH. Praveen Kumar , K. Gnanaprakash , M. Gobinath
Keywords
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