ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF MULTICOMPONENTS IN BULK AND TABLET DOSAGE FORM
Journal Title: Int J of Preclin & Pharm Res - Year 2014, Vol 4, Issue 2
Abstract
ABSTRACT A simple, accurate, precise, and sensitive and a highly selective UV-spectrophotometric method were developed for the simultaneous estimation of atorvastatin calcium and pyridoxine hydrochloride at a maximum wavelength of 259 nm and 288 nm respectively. The method was found to be linear in the range of 2 – 10 μg/ml with mean recovery in the range of 98% -102% for atorvastatin calcium & pyridoxine hydrochloride. The developed method was validated according to ICH guidelines and it was found to be accurate and precise, thus the proposed method can be successfully applied for simultaneous determination of atorvastatin calcium & pyridoxine hydrochloride in routine analysis work. Keywords: Atorvastatin calcium (ATR), Pyridoxine hydrochloride (PYR), UV-Spectrophotometric method.
Authors and Affiliations
M. J. Jamadar*, M. S. Kondawar, K. A. Wadkar
Keywords
Related Articles
- EP ID EP90734
- DOI -
- Views 269
- Downloads 0
PRELIMINARY PHYTOCHEMICAL AND PHARMACOGNOSTICAL STANDARDIZATION OF AERIAL PARTS OF MERREMIA TRIDENTATA (LINN) HALLIER.F. CONVOLVULACEAE
ABSTRACT The aerial parts of Merremia tridentata (Linn) Hallier.f. of Convolvulaceae is used for hair growth promotion in folklore medicine. In the present investigation a detailed pharmacognostical study of aeri...
ANALYSIS OF IR – SPECTROSCOPY BY USING DIFFERENT NELUMBO NUCIFERA SAMPLES
ABSTRACT The present paper deals with the analysis of IR – spectrum by Nelumbo nucifera flower and silver nanoparticles. Sepcies of Nelumbo nucifera flower reportedly used in traditional systems of medicine. Natu...
AN OVERVIEW ON HPLC, UPLC AND ITS TROUBLESHOOTING
ABSTRACT HPLC and UPLC Systems take advantage of technological strides made in particle chemistry performance, system optimization, detector design, and data processing and control. When taken together, these ach...
SPECTROPHOTOMETRIC ESTIMATION OF CEFPROZIL IN BULK DRUG AND PHARMACEUTICAL FORMULATIONS
ABSTRACT Two simple, accurate, rapid and sensitive spectrophotometric methods (A and B) have been developed for estimation of cefprozil in bulk drug and pharmaceutical formulations. The methods A and B were based...
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION AND STABILITY STUDIES OF THE ESTIMATION OF AGOMELATINE IN TABLET DOSAGE FORM BY RP-HPLC
ABSTRACT Agomelatine is a new melatonergic antidepressant with a unique pharmacological action. A stability indicating RP-HPLC method was developed and validated for the determination of agomelatine in active pharm...