SPECTROPHOTOMETRIC ESTIMATION OF CEFPROZIL IN BULK DRUG AND PHARMACEUTICAL FORMULATIONS
Journal Title: Int J of Preclin & Pharm Res - Year 2012, Vol 2, Issue 2
Abstract
ABSTRACT Two simple, accurate, rapid and sensitive spectrophotometric methods (A and B) have been developed for estimation of cefprozil in bulk drug and pharmaceutical formulations. The methods A and B were based on oxidation of Cefprozil with ferric chloride followed by complex formation with MBTH (3-methyl-2-benzothiazolinone hydrazone) and 1,10- phenanthroline, respectively. The complex shows maximum absorbance at 658 nm and 510 nm for method A and B respectively. The beers law concentration range is 100-500 mcg/ml and 2-10 mcg/ml for method A and B respectively. The results of all the methods were validated statistically and by recovery studies. The proposed methods are economical and sensitive for the estimation of Cefprozil in bulk drug and tablet dosage form. Keywords: Ultraviolet-Visible Spectrophotometry, Cefprozil, MBTH, 1,10-Phenanthroline.
Authors and Affiliations
Manzoor Ahmed**, Patel Tejendrakumar A*, Sathish Kumar Shetty A
Keywords
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