DEVELOPMENT AND VALIDATION OF HPLC METHOD FOR DETERMINATION OF ROXITHROMYCIN FROM HUMAN PLASMA
Journal Title: Int J of Preclin & Pharm Res - Year 2014, Vol 4, Issue 1
Abstract
ABSTRACT A stable, simple, rapid, precise, accurate HPLC method for analysis of Roxithromycin was developed and validated as per ICH guidelines without need of any internal standard. Separation was carried out using X’terra RP18 (250*4.6) mm, 5µ column with potassium dihydrogen orthophosphate buffer (pH 3): acetonitrile (30:70 v/v) as mobile phase with flow rate 1 mL min-1 . The parameters studied were retention time, linearity and range, accuracy, precision. The proposed method can be used for determination of Roxithromycin from Human plasma. Keywords: Roxithromycin, HPLC, Validation
Authors and Affiliations
*Rajesh Chaudhari
Keywords
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