DEVELOPMENT AND VALIDATION OF LORATADINE IN BULK AND PHARMACEUTICAL DOSAGE FORM BY UV SPECTROSCOPIC METHOD
Journal Title: Int J of Preclin & Pharm Res - Year 2014, Vol 4, Issue 1
Abstract
ABSTRACT A simple UV spectroscopic method was developed and validated for the estimation of loratadine in bulk and pharmaceutical dosage form using acetonitrile as solvent. The quantification was achieved at 250nm. Beers law was obeyed in the concentration range of 4-24 μg/ml. The results of analysis have been validated statistically and recovery studies carried out in the range 80-120% to confirm the accuracy of the proposed method. The relative standard deviation was found to be less than 2.0%. The assay result of marketed formulation was found to be 99.46% pure. The present result shows that the proposed method can be successfully implemented for estimation of loratadine in bulk and its marketed formulations. Keywords: UV Spectroscopy, Loratadine, Acetonitrile.
Authors and Affiliations
K. B. Shalini,*, Nalini Kanta Sahoo , B. Gopinadh , T. Jyothi , P. Vijay Kumar
Keywords
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