ANALYTICAL TECHNIQUES FOR THE ESTIMATION OF FENOFIBRATE IN BULK AND PHARMACEUTICAL DOSAGE FORMS: A REVIEW
Journal Title: Int J of Preclin & Pharm Res - Year 2014, Vol 4, Issue 8
Abstract
ABSTRACT Fenofibrate which is chemically propan-2-yl 2-{4-[(4-chlorophenyl) carbonyl] phenoxy}-methyl propanoate. It is mainly used to reduce cholesterol levels in patients at risk of cardiovascular disease. Like other fibrates, it reduces low-density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels, as well as increasing high density lipoprotein (HDL) levels and reducing triglycerides levels. It also appears to have a beneficial effect on the insulin resistance featured by the metabolic syndrome. . Literature survey reveals that Fenofibrate is estimated individually by UV spectrometry, RP-HPLC, LC/MS, LC/MS/MS and stability indicating HPLC. Keywords: Fenofibrate, UV spectrometry, RP-HPLC, LC/MS, LC/MS/MS.
Authors and Affiliations
B. Chinnappadu* , A. Ajitha , Uma Maheswara Rao
Keywords
Related Articles
- EP ID EP143897
- DOI -
- Views 124
- Downloads 0
DEVELOPMENT OF A STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF TRIMETHOPRIM, SULFAMETHOXAZOLE AND METYHL PARABEN IN ORAL SUSPENSION
ABSTRACT A gradient Simultaneous estimation by RP-HPLC Method were developed and validated for the quantification of Trimethoprim, Sulfamethoxazole and methyl paraben at single wavelength (275nm) in order to asse...
DIFFERENCE ABSORBANCE SPECTROPHOTOMETRIC DETERMINATION OF OFLOXACIN AND ORNIDAZOLE IN DOSAGE FORM
ABSTRACT Describing the simple, precise and rapid method based on difference absorbance spectroscopic technique for the determination of Ofloxacin (OF) and ornidazole (OZ) in tablet dosage form. The projected met...
RECENT APPLICATIONS OF FLOW INJECTION SPECTROPHOTOMETRY
ABSTRACT Pharmaceutical analysis is one of the most important fields in analytical chemistry. The discovery of new drugs and the on-going update of international regulations for the safety and efficacy of pharmac...
DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE UV SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF TENOFOVIR DISOPROXIL FUMARATE, LAMIVUDINE AND EFAVIRENZ IN BULK AND TABLET DOSAGE FORM
ABSTRACT A simple, sensitive, rapid, economic and accurate first order derivative spectrophotometric method has been developed for estimation of Tenofovir disoproxil fumarate (TDF), Lamivudine (LAM) and Efavirenz...
SUPER CRITICAL FLUID CHROMATOGRAPHY: AN OVERVIEW
ABSTRACT Supercritical Fluid Chromatography (SFC) is a form of normal phase chromatography, first used in 1962.SFC typically utilizes carbon dioxide as the mobile phase; therefore the entire chromatographic flow...