ANALYTICAL TECHNIQUES FOR THE ESTIMATION OF FENOFIBRATE IN BULK AND PHARMACEUTICAL DOSAGE FORMS: A REVIEW
Journal Title: Int J of Preclin & Pharm Res - Year 2014, Vol 4, Issue 8
Abstract
ABSTRACT Fenofibrate which is chemically propan-2-yl 2-{4-[(4-chlorophenyl) carbonyl] phenoxy}-methyl propanoate. It is mainly used to reduce cholesterol levels in patients at risk of cardiovascular disease. Like other fibrates, it reduces low-density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels, as well as increasing high density lipoprotein (HDL) levels and reducing triglycerides levels. It also appears to have a beneficial effect on the insulin resistance featured by the metabolic syndrome. . Literature survey reveals that Fenofibrate is estimated individually by UV spectrometry, RP-HPLC, LC/MS, LC/MS/MS and stability indicating HPLC. Keywords: Fenofibrate, UV spectrometry, RP-HPLC, LC/MS, LC/MS/MS.
Authors and Affiliations
B. Chinnappadu* , A. Ajitha , Uma Maheswara Rao
Keywords
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