ANTI-CANCER POTENTIAL OF FUCOIDAN EXTRACTED FROM PADINA DISTROMATICA HAUCK (BROWN SEAWEED) FROM HARE ISLAND, THOOTHUKUDI, TAMIL NADU, INDIA
Journal Title: Asian J of Pharm Sci & Tech - Year 2014, Vol 4, Issue 4
Abstract
ABSTRACT The present research was aimed to evaluate the anti-cancer potential of fucoidan extracted from Padina distromatica Hauck in Hare Island, Thoothukudi, Tamil Nadu, India for the inhibitory effect against A-431, A-549, HL-60, HT-29 and MCF-7 cell lines. The viability percentage of the cell lines were carried out by using Trypan blue dye exclusion method and the cytotoxicity of fucoidan of Padina distromatica Hauck on A-431, A-549, HL-60, HT-29 and MCF-7 cell lines were evaluated by MTT assay. The fucoidan from Padina distromatica Hauck has significant cytotoxicity effect on A-549 cell line followed by moderate activity against HL-60 and A-431. However fucoidan was found to have less activity on HT-29 and MCF-7 in the concentration range between 250 to 1000µg/ml of fucoidan by using MTT assay. From the performed assay, it was concluded that fucoidan extracted from Padina distromatica Hauck shows greater activity on all the tested cell lines which can be used as anti-cancer activity. Key words: Anti-cancer, Cell lines, Fucoidan, Seaweeds, Padina.
Authors and Affiliations
John Peter Paul J*
Keywords
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