Anti-HIV-1 activities of extracts and phenolics from Smilax china L.

Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2014, Vol 27, Issue 1

Abstract

 Four extracts (EtOH, CHCl3, EtOAc, and BuOH) and five phenolics (dihydrokaempferol (1), resveratrol (2), kaempferol-7-O-β-D-glucoside (3), dihydrokaempferol-3-O-α-L-rhamnoside (4), oxyresveratrol (5)) from Smilax china L. was evaluated for anti-HIV-1 activities and cytotoxicity activities in vitro. All these extracts and phenolics showed lower or no cytotoxicity at a concentration ranged from 0.8 µg/mL to 100 µg/mL, but some showed potential anti-HIV-1 activities, that is, BuOH extract and compound 2 showed higher anti-HIV-1 activities than other extracts and compounds in the tested concentrations. EtOAc extract and compound 1 and 3 showed moderate anti-HIV-1 activities at a concentration higher than 4 µg/mL. In the end, the structure-activity relationship of four extracts and five phenolics was discussed.

Authors and Affiliations

Wei-Xin Wang , Jing-Yi Qian , Xiao-Jing Wang , Ai-Ping Jiang , Ai-Qun Jia

Keywords

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  • EP ID EP162309
  • DOI -
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How To Cite

Wei-Xin Wang, Jing-Yi Qian, Xiao-Jing Wang, Ai-Ping Jiang, Ai-Qun Jia (2014).  Anti-HIV-1 activities of extracts and phenolics from Smilax china L.. Pakistan Journal of Pharmaceutical Sciences, 27(1), 147-151. https://europub.co.uk/articles/-A-162309