In vitro antimalarial and xanthine oxidase inhibition of 2- Aminoanthraquinone
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2016, Vol 29, Issue 2
Abstract
In the present research study 2-Aminoanthraquinone were scrutinized for their antimalarial and Xanthine oxidase inhibitor potential. It demonstrated marked concentration dependent antimalarial activity with maximum effect of 89.06% and with IC50 of 34.17 µM. Regarding Xanthine oxidase inhibitor activity, it evoked significant effect with 57.45% activity with IC50 value of 81.57.19µM. In conclusion, 2-Aminoanthraquinone showed potent antimalarial and xanthine oxidase inhibitory activity.
Authors and Affiliations
Abdur Rauf , Rehan Khan , Haroon Khan , Noor Jehan , Mohammad Akram, , Zarka Ahmad , Naveed Muhammad , Umar Farooq , Ajmal Khan
Keywords
Related Articles
- EP ID EP90687
- DOI -
- Views 125
- Downloads 0
Heparin-induced thrombocytopenia associated with cardiopulmonary bypass: Preliminary attempt with recombinant human thrombopoietin therapy
Recombinant human thrombopoietin (rhTPO) is popularly used for the treatment of chemotherapy-induced thrombocytopenia. However, rhTPO therapy for heparin-induced thrombocytopenia relating to cardiopulmonary bypass...
Beneficial effects of mangiferin isolated from Salacia chinensis on biochemical and hematological parameters in rats with streptozotocin-induced diabetes
Salacia chinensis L. is a traditional Southeast Asian herbal medicine and used in the treatment of diabetes. To investigate the antidiabetic properties of mangiferin from Salacia chinensis and its beneficial effect...
Vitamin D and the prevention of preeclampsia: A systematic review
To identify the effect of Vitamin D in reducing the risk of preeclampsia in pregnant women. The review was conducted from December 2011 to March 2012 at the University of Sheffield. Studies were included from the Medline...
Formulation and in-vitro evaluation of floating bilayer tablet of lisinopril maleate and metoprolol tartrate
The purpose of this study was to introduce the technology for the development of rate-controlled oral drug delivery system to overcome various physiological problems. Several approaches are being used for the purpo...
In vivo evaluation & safety profile evaluation of Arctostaphylos uva-ursi (L.) Spreng. extract in rabbits
The aim of our research work was to investigate the effects of low dose of Arctostaphylos uva-ursi (L.) Spreng. on rabbits. Crude extract was administered for 90 days in rabbits and hematology, biochemistry paramet...