Anti hyperalgesic potentials of Laggera aurita in Swiss Albino mice
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2014, Vol 27, Issue 1
Abstract
The ethnomedical uses of Laggera aurita (LA), including its anti-nociceptive properties have been documented in literature. This study evaluated the anti-hyperalgesic effects of the methanolic extract of LA (MELA) using chemically and mechanically induced hyperalgesia models. Acute toxicity and preliminary phytochemical screening were also conducted. The intraperitoneal median lethal dose was found to be 3807.88 mg/kg, while saponins, tannins and carbohydrates were found to be present in the plant material. MELA exhibited significant analgesic activity in the acetic acid induced writhing and Randall-Siletto tests. The 400 mg/kg dose of MELA exhibited a significant (p<0.001) analgesic activity which offered 19.75% inhibition above piroxicam in the acetic acid test. At 200 and 400 mg/kg MELA demonstrated comparative analgesia with pentazocine in the Randall-Siletto test. The study shows that MELA possesses anti-nociceptive principles and the presence of saponins, tannins and carbohydrates which have been previously associated with anti-hyperalgesia may be responsible for the pharmacological actions, thus authenticating the ethnomedical rationale for its anti-nociceptive uses.
Authors and Affiliations
Temidayo Olutoyin Olurishe , Fatima Guiet Mati
Keywords
Related Articles
- EP ID EP151972
- DOI -
- Views 69
- Downloads 0
Design and content determination of nimesulide injectable formulation
The aim of the present study was to formulate Nimesulide inject able solution, establish a method for content determination, and accumulate data for registration of a new Nimesulide formulation. The optimal Nimesul...
Clinical study of ganglioside (GM) combined with methylprednisolone (MP) for early acute spinal injury
This paper aims to make an analysis of the effects of ganglioside (GM) combined with methylprednisolone (MP) in early acute spinal injury. Fifty-three patients with acute spinal cord injury were included in this st...
Evaluation and comparison of different brands of domperidone tablets available in Karachi, Pakistan
Domperidone is an anti-dopaminergic drug used for the treatment of nausea, vomiting and dyspepsia. It has also been used in Parkinson’s disease. In this study, five different brands of Domeperidone tablets were sel...
Dengue fever: Natural management
Dengue fever is caused by the mosquito-borne dengue virus (DENV) serotypes 1-4, and is the most common arboviral infection of humans in subtropical and tropical regions of the world. Dengue virus infections can present w...
The influence of joint application of arsenic trioxide and daunorubicin on primary acute promyelocytic leukaemia cells and apoptosis and blood coagulation of cell strain
This test cultivated three groups of acute promyelocytic leukemia (APL) and NB4 cells in liquid in vitro, processed them with arsenic trioxide (ATO), daunorubicin (DNR), ATO+DNR respectively, and then set up blank...