Anticancer activity of Cinnamon tamala leaf constituents towards human ovarian cancer cells
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 3
Abstract
Bioassay guided fractionation of Cinnamon tamala leaf extracts yielded bornyl acetate (1), caryophylene oxide (2), p-coumaric acid (3) and vanillic acid (4) using A-2780 human ovarian cancer cell lines. The structures of the isolated compounds were confirmed through spectroscopic techniques (EIMS, 1 H and 13C NMR). Compound 1 exhibited highest cytotoxicity with 90.16±1.06% inhibition (IC50=5.30 x 10-4 mg/ml) followed by compound 2 (84.40±1.53% inhibition; IC50=8.94 x 10-3mg/ml), while compounds 3 and 4 were inactive in the bioassay.
Authors and Affiliations
Durre Shahwar , Sami Ullah , Mohammad Akmal Khan , Naeem Ahmad , Afifa Saeed , Saif Ullah
Keywords
Related Articles
- EP ID EP95047
- DOI -
- Views 93
- Downloads 0
Proteomic analysis of Corylus heterophylla fisch in Changbai Mountain by shotgun approach
Total proteins of Changbai Mountain hazelnut were extracted and then enzymolysed in solution. The mixture of peptides was separated on chromatograph and identified by shotgun proteomics approach. The identified pro...
Determination of total phenolics, flavonoid contents and antioxidant activity of different mBHT fractions: A polyherbal medicine
In this study, antioxidant activity, total phenolic and flavonoids content of four different fractions from the traditional Korean polyherbal medicine of Modified Bo-yang-Hwan-o-Tang (mBHT) was determined using spe...
Potential antibacterial activity of coumarin and coumarin-3-acetic acid derivatives
Coumarin and coumarin-3-acetic acid derivatives were synthesized by reacting phenols with malic acid, ethyl acetoacetate and ethyl acetylsuccinate in appropriate reaction conditions. All synthesized compounds were...
Simultaneous quantitation of aspirin, amlodipine and simvastatin in a fixed dose combination of encapsulated tablet formulation by HPLC-UV method
A high-pressure liquid chromatography (HPLC-UV) based simple and specific method for simultaneous quantitative determination of aspirin, amlodipine besylate and simvastatin in a capsule formulation has been develop...
Utilization of spray drying technique for improvement of dissolution and anti-inflammatory effect of Meloxicam
Meloxicam (MLX) is a poorly water-soluble non steroidal anti-inflammatory drug (NSAID). The main objective of the present work was to enhance the dissolution of MLX and thus its bioavailability by the aid of additi...