ANTICOAGULANT ACTIVITY OF ETHANOL AND AQUEOUS EXTRACTS OF PETROSELINUM CRISPUM MILL.
Journal Title: Int J of Pharm Rev& Res - Year 2016, Vol 6, Issue 1
Abstract
ABSTRACT This Study is designed to evaluate the Anticoagulant activity of Petroselinum crispum Mill. Anticoagulants are administered to patients with myocardial infarction, venous thrombosis, peripheral arterial emboli and pulmonary emboli and prevent transient ischemic attacks and to reduce the risk of recurrent myocardial infarction. The male wister albino rats were divided into 7 groups of Six animals. Group I served as a control. Group II rats were administered with Phytomena (10mg/kg) orally. Group III rats were administered with standard drug of Warfarin sodium (5mg/kg) orally. Group IV,V animals were administered with ethanol extract of Petroselinum crispum Mill. (200mg/kg & 400mg/kg respectively) orally. Group VI,VII animals administered with aqueous extract of Petroselinum crispum Mill. (200mg/kg,400mg/kg respectively) orally. After the end of the absorption time, they are anesthetized by intravenous injection of 60 mg/kg sodium pentobarbital. The retro-orbital bleeding method was employed to collect 1.8ml blood into a plastic syringe containing 0.2 ml 100 mM citrate buffer ph 4.5 (Behring werke, Marburg). The sample is immediately agitated and centrifuged in a plastic tube at 1500 g for 10 min. Plasma is transferred to another plastic tube and the coagulation test for the determination of thrombin time (TT), thromboplastin time (PT) and activated partial thromboplastin time (APTT)were performed within3 hr. Ethanol and aqueous extract of Petroselinum crispum mill leaves, whose anticoagulant effectiveness is comparable to that of its commercial counterpart, warfarin, (Group III) showed a positive inhibition of clot formation with significant prolonged a PTT, PT, TT activated time. In all Aqueous extract(400mg/kg) of Petroselinum crispum Mill. found to be significant and most effective than ethanol extracts in positive anticoagulation effect. In all, it is obvious that it can be used as cardioprotector. Key words: Anticoagulant activity, Cardioprotector, Petroselinum crispum Mill., Warfarin sodium.
Authors and Affiliations
Vannamalar S* and B Jaykar
Keywords
Related Articles
- EP ID EP154252
- DOI -
- Views 77
- Downloads 0
DIETARY SOURCE OF ANTI CANCER AGENTS
Cancer is the second leading cause of death worldwide. There are several medicines available in the market to treat the various types of cancer but no drug is found to be fully effective and safe. The major problem in th...
STUDY OF SUITABLE METHODS TO FACILITATE INDEPENDENT SELF ADMINISTRATION OF MEDICINES IN A GROUP OF BLIND AND PARTIALLY SIGHTED PERSONS IN SRI LANKA
Visually disabled persons face difficulties in self-administration of medicines. They have difficulty locating medicines, identifying different medicines, taking the correct dose and remembering verbal instructions given...
ANALYSIS OF WATER QUALITY PARAMETERS IN PONDS OF RATANPUR, BILASPUR DISTRICT, CHHATTISGARH
This paper present to study of the physico-chemical parameters of Ratanpur ponds in Bilaspur district, Chhattisgarh. Monthly changes in physical and chemical parameters such as water temperature, transparency, turbidity,...
Review on Diabetes Mellitus
Diabetes mellitus has reached epidemic proportions and affects more than 170 million individuals worldwide. In more developed societies, the prevalence of diabetes mellitus has reached about 6% and even more alarmingly,...
DEVELOPMENT AND INVITRO CHARACTERIZATION OF PACLITAXEL SUSTAINED RELEASE MICROSPHERS
The objective of the present work was to formulate and evaluate sustained release paclitaxel microspheres for treating breast, ovarian and colon cancer effectively. Sustained release paclitaxel microspheres for minimum f...