ANTICOAGULANT ACTIVITY OF ETHANOL AND AQUEOUS EXTRACTS OF PETROSELINUM CRISPUM MILL.
Journal Title: Int J of Pharm Rev& Res - Year 2016, Vol 6, Issue 1
Abstract
ABSTRACT This Study is designed to evaluate the Anticoagulant activity of Petroselinum crispum Mill. Anticoagulants are administered to patients with myocardial infarction, venous thrombosis, peripheral arterial emboli and pulmonary emboli and prevent transient ischemic attacks and to reduce the risk of recurrent myocardial infarction. The male wister albino rats were divided into 7 groups of Six animals. Group I served as a control. Group II rats were administered with Phytomena (10mg/kg) orally. Group III rats were administered with standard drug of Warfarin sodium (5mg/kg) orally. Group IV,V animals were administered with ethanol extract of Petroselinum crispum Mill. (200mg/kg & 400mg/kg respectively) orally. Group VI,VII animals administered with aqueous extract of Petroselinum crispum Mill. (200mg/kg,400mg/kg respectively) orally. After the end of the absorption time, they are anesthetized by intravenous injection of 60 mg/kg sodium pentobarbital. The retro-orbital bleeding method was employed to collect 1.8ml blood into a plastic syringe containing 0.2 ml 100 mM citrate buffer ph 4.5 (Behring werke, Marburg). The sample is immediately agitated and centrifuged in a plastic tube at 1500 g for 10 min. Plasma is transferred to another plastic tube and the coagulation test for the determination of thrombin time (TT), thromboplastin time (PT) and activated partial thromboplastin time (APTT)were performed within3 hr. Ethanol and aqueous extract of Petroselinum crispum mill leaves, whose anticoagulant effectiveness is comparable to that of its commercial counterpart, warfarin, (Group III) showed a positive inhibition of clot formation with significant prolonged a PTT, PT, TT activated time. In all Aqueous extract(400mg/kg) of Petroselinum crispum Mill. found to be significant and most effective than ethanol extracts in positive anticoagulation effect. In all, it is obvious that it can be used as cardioprotector. Key words: Anticoagulant activity, Cardioprotector, Petroselinum crispum Mill., Warfarin sodium.
Authors and Affiliations
Vannamalar S* and B Jaykar
Keywords
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