Application of High Performance Thin Layer Chromatography with Densitometry for Determination of Active Ingredients and Preservatives in Various Pharmaceutical Marketed Formulations
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2015, Vol 5, Issue 4
Abstract
High performance thin layer chromatography(HPTLC) is a fast separation technique which is advantageous in many means as it is simple to handle and requires a short analysis time to analyze the complex or the crude samples. A new, simple, precise and sensitive analytical method based on HPTLC technique has been developed and validated for the estimation of eighteen active ingredients and preservatives in various marketed pharmaceutical formulations. The proposed method was accurate and precise (mean recovery in the range from 83.3% to 98.8%, precision with RSD<3.95%; LOQ < 26.4 μg/mL). This method was applied for the quantification of active ingredients and preservatives in: ophthalmic solutions, nasal solution, otic solution, syrups, shampoos, suppositories, ointments, dietary supplements, tablets and capsules.
Authors and Affiliations
Vesna Kostik
Keywords
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