Estimation the level of il-17a in a sample of type i diabetes mellitus patients
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2014, Vol 4, Issue 6
Abstract
Type 1 diabetes mellitus (T1 DM) is a chronic autoimmune disease associated with selective destruction of insulin-producing pancreatic β-cells. Several features characterize type 1 DM as an autoimmune disease: presence of immuno-competent and accessory cells infiltrated pancreatic islets. This is a prospective study which was carried out to investigate the possible association of T1 DM with IL-17A. Sixty patients with Type 1 diabetes mellitus (T1 DM) who were diagnosed according to American Diabetes Association criteria (ADA) 1997 were selected from the Center of Endocrinology and Diabetes /AL-Kindey / Hospital/Baghdad. All patients were treated with daily replacement doses of insulin. Their age ranged 5- 40 years. As a control group, sixty apparently healthy volunteers whose their age (8- 40) years, and sex (Females: Males 1:1.31) were matched the patients' group. The study revealed that the high frequencies of T1 DM was at the age group 10-19 years while the lower frequency among age group <10 years old. Regarding cytokine level, it was noticed that there was highly significant elevation in the mean of IL-17A in the sera of diabetic group (1312.06 Pg/ ml) in comparison with healthy control (332.28 pg/ml) (P=0.003). Conclusion, there appears to be an important role for IL-17A in increasing the chance of enhancing the susceptibility for disease development or providing protection against it.
Authors and Affiliations
1, Amani Mahmood Tuama (MsC), 2, Hiba Abid Al-Hussein Hassan (MsC), 3, Khaleel Ibrahim Rashid (PhD)
Keywords
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