ASYMPTOMATIC BACTERIURIA IN HIV/AIDS PATIENTS: OCCURRENCE AND RISK ASSOCIATED WITH LOW CD4 COUNTS.
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2013, Vol 2, Issue 19
Abstract
[b] BACKGROUND[/b]: People living with HIV/AIDS with progressive immune dysfunction have an augmented risk of Urinary tract infection, both symptomatic and asymptomatic, in comparison to non-infected individuals. [b]AIMS[/b]: This prospective study was planned to know the frequency of asymptomatic bacteruria (ASB) in HIV sero-positives and its correlation to their immune status. Conventional culture method was compared with screening test using SD Urocolor TM 10 test strips for the presence of infection. Antibiogram of isolated uropathogens were analysed to understand the trends of drug resistance. [b]SETTINGS AND DESIGN[/b]: Prospective Cohort Study. [b]MATERIALS AND METHODS[/b]: Clean catch midstream urine samples collected from 270 HIV seropositive patients and 100 seronegative controls were screened for ASB by Urostrip urinalysis, Gram stain and culture. Antibiogram of significant growth isolates was done by Kirby-Bauer disc diffusion method. Their immune status was evaluated by CD4 + cell counting. [b]STATISTICAL[/b] [b]ANALYSIS USED[/b]: Sensitivity, Specificity, Odds ratio, Fisher extract test. [b]RESULTS[/b]: ASB was detected in 5.6% (15/270) of HIV sero-positives and 1% (1/100) of seronegatives controls.13/15 HIV seropositive ASB cases had CD4 cell counts < 350 cells/ μL. The gram stain and urostrips had sensitivity of 93.33% & 80% and a specificity of 95.68% & 60.39% respectively. [b]CONCLUSIONS[/b]: Occurrence of ASB was significantly high among the HIV sero-positives with CD4 cell counts < 350 cells/ μL. Conventional culture and gram staining continue to be the proficient methods for detecting ASB. Cotrimaxazole prophylaxis hardly influenced the presence of ASB in HIV sero-positives
Authors and Affiliations
Rashmi K. S, Ravikumar K. L, Jagadeesh , Nimitha , Bhagyashree H. N
Keywords
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