C-reactive protein level and obesity as cardiovascular risk factors in polycystic ovary syndrome
Journal Title: Dicle Tıp Dergisi - Year 2013, Vol 40, Issue 3
Abstract
tive: To investigate the role of C-reactive protein (CRP) level elevation and obesity for the increased cardiovascular disease risk in polycystic ovary syndrome (PCOS). Methods: A hundred and nine patients with PCOS and 30 age matched healthy volunteers with regular menstrual cycle are involved in the study. PCOS group is further subdivided into three subgroups according to the body mass index (BMI). Subgroups included 54 with BMI<25, 22 with BMI 25-30, and 33 with BMI>30. Blood samples for glucose, insulin, uric acid, and CRP were collected in the morning after overnight fasting (12 hours). Homeostasis model assessment-insulin resistance (HOMA-IR) was calculated. Results: Fasting blood glucose, insulin, and HOMA-IR was significantly higher in PCOS group (p=0.02, p=0.01 and p=0.02). CRP level was higher in subgroup with BMI>30. High CRP level in PCOS was found to be independent from BMI (p<0.001). HOMA-IR and insulin level was higher in the subgroup with BMI>30. When compared with the control group high insulin level was the only to be statistically significant in obese PCOS patients (p=0.005). HOMA-IR was higher in PCOS subgroup with BMI>30 when compared with controls and the PCOS subgroup with BMI<25 (p<0.001, p= 0.003). Conclusion: Obesity, hyperinsulinemia, and high CRP levels are seemed to be related and potentiating each other in PCOS. Struggling with obesity is one of the most important issues for preventive medicine. Key words: PCOS, CRP, obesity, cardiovascular risk
Authors and Affiliations
Eda Uludağ , İlay Gözükara, Suna Kucur, Havva Keskin, Zeynep Kamalak, Ayşe Kargılı, Şenay Durmaz
Keywords
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- EP ID EP156909
- DOI 10.5798/diclemedj.0921.2013.03.0303
- Views 113
- Downloads 0
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