Can venous blood gas analysis replace arterial blood gas analysis in patients with diabetic ketoacidosis?
Journal Title: International Journal Of Research In Medicine - Year 2014, Vol 3, Issue 1
Abstract
BACKGROUND: Diabetic ketoacidosis (DKA) is a life-threatening endocrine emergency, traditionally requiring arterial blood gas (ABG) analysis for diagnosis and monitoring. The aim of our study was to assess the comparability of arterial and venous blood samples for pH and bicarbonate measurements in patients with DKA. MATERIALS AND METHODS: Prospective, observational study of patients with suspected DKA coming to ED (Emergency department) was carried out. Inclusion criteria were capillary blood glucose equal to or greater than 250 mg/dL, ketonuria, and clinical signs and symptoms of DKA. Patients with coexisting respiratory or renal diseases and hemodynamic instability were excluded from the study. ABG and VBG (Venous blood gas) samples were taken simultaneously (within 2 minutes) before treatment. Pearson’s correlation coefficient and Bland-Altman bias plot were used to compare pH and bicarbonate values of arterial and venous blood samples. RESULTS: Data from 50 episodes of diabetic ketoacidosis in 50 patients were analyzed. Laboratory findings of those patients with diabetic ketoacidosis were as follows (mean±SD): arterial pH, 7.131±0.139; venous pH, 7.108±0.147; serum glucose, 442±113 mg/dL; arterial HCO3–, 6.104±3.133 mmol/L and venous HCO3–, 6.234±3.358 mmol/L. The mean difference between arterial and venous pH values was 0.022 (range 0.0 to 0.054). Arterial and venous pH results (r=0.9959) and arterial and venous HCO3– results (r=0.9025) were highly correlated and showed a high degree of agreement. CONCLUSION: A venous blood sample is sufficiently reliable to assess pH and bicarbonate in patients with DKA suggesting that venous sampling alone is appropriate in the management of DKA.
Authors and Affiliations
Shruti Sangani1* , Jigarkumar Gosai1 , Dhara Gosai2 , Samira Parikh3
Keywords
Related Articles
- EP ID EP138246
- DOI -
- Views 178
- Downloads 0
Prehypertension among medical students: The prevalence and risk factors
BACKGROUND AND OBJECTIVES: The problem of hypertension is growing very rapidly in India with a prevalence of nearly 30% from a very recent systematic review. Prehypertension, the preceding reversible stage, defined as sy...
Effect of Kangaroo Mother Care on Growth Parameters of Low Birth Weight Neonates
BACKGROUND: To evaluate the effect of Kangaroo Mother Care(KMC) on growth parameters of low birth weight(LBW) neonates. METHODS: Prospective follow-up cohort study was carried out at NICU of Civil Hospital, Ahmedabad fro...
Sickle Cell Disease: Prevalence, Clinical Presentation and Prognosis in Tribes; Current Concepts and Unanswered Question
BACKGROUND: Sickle cell Disease is one of the most common severe monogenic disorder in the world. It is characterized by intermittent Vasoocclusive events and chronic Hemolytic Anemia. Patients clinically present with ea...
Study of Clinical Profile of 70 Cases of Hypertension in Pregnancy
BACKGROUND AND OBJECTIVES: Hypertensive disorders of pregnancy & their complications are one of the most common cause of maternal morbidity in world. In India the incidence of Hypertension is reported to be 8-10% of the...
A study on menstrual practices among adolescent girls residing in urban slums of Visakhapatnam city of Andhra Pradesh State
BACKGROUND: What are the menstrual practices followed by adolescent residing in urban slums of Visakhapatnam city? Objectives: To study the socio-demographic profile of adolescent girls of urban slum and the mens...