Clinical Significance of 99mTc-MDP Imaging & Molecular Biology in the Diagnosis of Bone Metastases
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2014, Vol 4, Issue 2
Abstract
Breast cancer is a leading cause of cancer death among women. Skeletal metastases are clinically significant because of associated symptoms, complications such as pathological fractures and their profound significance for staging treatment and prognosis. Detection of bone metastatic lesions allows radiation therapy or surgical interventions to prevent pathological fractures from disabling the patients. High sensitivity of bone scanning in determining the presence and extent of metastatic disease makes extremely important tool in decision making. Bone scans demonstrate metastatic lesions much earlier than X-ray,C.T.,MRI. To help diagnose pathology of the skeletal system, patients are injected with radiopharmaceuticals composed of Technetium-99m and a bone-seeking molecule such as analogs of calcium, hydroxyl groups or phosphates. In fact the most commonly used molecule is organic diphosphonate bound to Tc-99m. These patients are then scanned by a gamma camera 2-4 hours later; typically, both anterior and posterior scans are taken.Purpose of study was to diagnose, staging and see the treatment response in breast cancer patients. 99mTechnetium methylene di-phosphonate (99mTc MDP) bone scintigraphy was performed for the detection of bone metastases in histopathologically proven patients of breast cancer. 53 patients of breast cancer were investigated with gamma camera. On visual analysis there was positive scan findings (bone metastases) in 19 patients (35.84 %) and negative scan findings (normal bone scan) in 34 patients (66.6%). 99mTc-MDP skeletal scintigraphy elucidates, non-invasively, tumour characteristics and may be indicative for prognosis and response to chemotherapy and hormonal treatment.
Authors and Affiliations
Dr. Karan Peepre1 , A. N. Tiwari1 , J. P. Sharma1 , Dr. Karan Peepre
Keywords
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