Clostridium Difficile infection and Antibiotic –Associated Colitis
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2014, Vol 4, Issue 5
Abstract
Hospitalized patients receiving β lactam antibiotics develop diarrhea and higher rates reported in those receiving clindamycin. Clostridiumdifficile is recognized as a cause of antibiotic associated diarrhea, colitis and pseudomembranous colitis. Contributory factors include: advance age, severity of underlying illness.C.difficile has the ability to temporarily colonize newborn humans and calves, suggests that the gastrointestinal tracts of young animals may be a major reservoir.C.difficile is recognized enteric pathogen in animals including companion animals and food animals. Clinical features include: asymptomatic carriage in neonates to a fulminant, relapsing, and occasionally fatal colitis. Initial therapy for pseudomembranous colitis includes discontinuation of offending antibiotic regimen, fluid replacement and electrolyte losses. Mild to moderate infection with metronidazole,severe to recurrent cases with ancomycinTherapy with probiotic such as Sacchromyces boularadii is beneficial. Antibiotic misuse in humans and production animals must be addressed.
Authors and Affiliations
Murtaza Mustafa1 ,Muhammad Iftikhar2 ,,Malik J. Shah4 , Saima Shafi
Keywords
Related Articles
- EP ID EP99599
- DOI -
- Views 123
- Downloads 0
The Comprehensive Review on Fat Soluble Vitamins
This review article deals with brief description of fat soluble vitamins with figures and tables showing statistical analytical data duly quoting the references wherever necessary. The word “soluble actually me...
[b] A histological study on acrylamide and cadmium chloride altered chick embryonic liver[/b]
Dynamics of Combined Oral Contraceptive: A Study of Some Cytokines in Female Wistar Rats
Oral contraceptives are a simple form of contraception used by women worldwide. The oral contraceptive is one of the greatest and most influential developments of the twentieth century. It is regarded as the...
Clinical, pharmacokinetic and technological aspects of the hydroxychloroquine sulfate
Developed originally as an antimalarial agent, hydroxychloroquine sulfate (HCQS) is often used as a slow-acting drug in treating disorders of connective tissue. Over the past two decades, several data have been a...
Determination of antibacterial activity of Green Coffee Arabica bean extract on Multidrug resistance Pseudomonas aeruginosa (ATCC 27853)
The emergence of drug resistant pathogens becomes a crucial problem for infectious diseases worldwide. Among these bacteria, P.aeruginosa is one of which highly resists to many currently used drugs and becomes a major co...