Compare the Efficacy of Escitalopram and Amitriptyline to reduce the Suicidal Risk in Depression patients
Journal Title: Journal of Medical Science and Technology - Year 2015, Vol 4, Issue 1
Abstract
Depression is the one of the leading cause of disability for both males and females, the burden of depression is 50% higher for females than males. To evaluate and compare the efficacy of Escitalopram (SSRI) and Amitriptyline (TCA) in reducing suicidal risk in patients with depression. Patients attending the OPD of Psychiatry department of MIMS were screened for selection criteria after obtaining written informed consent. After fulfilling the selection criteria, patients were randomized into two groups. Group – 1 were kept on tablet Amitriptyline 50mg /BD for 6 weeks and Group – 2 were on tablet Escitalopram 10 mg/BD for 6 weeks. Total 60 patients who were newly diagnosed with moderate –severe depression after fulfilling the selection criteria were included in our study. The study duration for each patient entering the study was 6 weeks. The results shows HAM-D, Pre & post treatment for Group 1 (Amitriptyline group) was significant (<0.001)*. P value of BSIS, Pre & Post treatment for Group 1 (Amitriptyline group) was significant (<0.001). (P< 0.05 is considered as significant). p value of HAM-D before & after treatment for Group 2 (Escitalopram group) was significant (<0.001)*. P value of BSIS before & after treatment for Group 2 (Escitalopram group) was significant (<0.001). Decreased suicidal risk, after treatment of Amitriptyline & Escitalopram (P value significant for both treatment groups). Suicidal behavior correlates with inadequate prescription of antidepressants. In the most antidepressant prescriptions are for female patients and most suicides are committed by male individuals.
Authors and Affiliations
Baswaraj Munge, Bhavitha Gurram, Mundllamudi Naidu, Bandopadhyay Mamata
Keywords
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