Controlled release matrix tablets of glipizide: Influence of different grades of ethocel and Co-excipient on drug release
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2016, Vol 29, Issue 3
Abstract
The aim of the current study was to formulate and evaluate glipizide controlled release matrix tablets by means of different grades of polymer Ethoceland different co-excipients in order to evaluate their effect on drug release profiles during in vitro dissolution studies. Type II diabetes mellitus is usually treated with Glipizide. Glipizide belongs to sulfonylurea group. Gastric disturbance and severe hypoglycemia has been observed after taking glipizide orally. To overcome these problems, controlled release matrices were developed using different grades of ethyl cellulose polymer with a drug-polymer ratio of 1:3by the direct compression method. The effect on drug release of partial replacement of lactose by different co-excipients, HPMC K100M, starch and CMC, were also studied. Diameter, thickness, hardness, friability, weight variations, drug contents of formulations were tested, these properties were within prescribed limits. Co-excipients and polymer containing formulations were compared to the without co-excipients and polymer containing formulations with respect to their release profile. After a 24-hour release study, ethyl cellulose polymer containing formulation exhibited prolonged release for 5-16 hours; however the polymer Ethocel® standard FP 7 Premium without co-excipient containing formulation exhibited controlled release for 24 hours. Incompatibility was investigated between drugs, co-excipient DSC and polymer study was performed and any type of interaction was not found. Different kinetic models were used to study the release mechanism. An enhanced release rate was observed in case of excipients containing formulations.
Authors and Affiliations
Saif Ullah Mehsud , Gul Majid Khan , Abid Hussain , Muhammad Akram , Muhammad Akhlaq , Kamran Ahmad Khan , Abdul Shakoor
Keywords
Related Articles
- EP ID EP90817
- DOI -
- Views 97
- Downloads 0
Antagonistic bacteria from live corals, tuticorin coastal waters, Southeastern India
The objective of this study is to isolate and production of secondary metabolites with bioactive substances by coral reef (Acropora formosa and Favia palida) associated bacteria was carried out from the Tuticorin coastal...
Effects of marmin, a compound isolated from aegle marmelos correa, on contraction of the guinea pig-isolated trachea
Marmin or 7-(6’,7’-dihydroxygeranyl-oxy)coumarin is a compound isolated from Aegle marmelos Correa. In the study, we examined the effects of marmin on the contraction of guinea pig-isolated trachea stimulated by several...
Effects of propolis on blood biochemical and hematological parameters in nitric oxide synthase inhibited rats by Nω-Nitro-L-arginine methyl ester
This study showed the effects of propolis on biochemical and hematological parameters in chronic nitric oxide synthase inhibited rats by Nω-Nitro-L-arginine methyl ester (L-NAME). Rats are given L-NAME for 15 days...
Biological Screening of Elaeagnus umbellata Thunb.
The bark and fruit extracts of Elaeagnus umbellata have been investigated for their antibacterial, anti-fungal, insecticidal and phytotoxic activities. The petroleum ether extracts of the plant showed significant a...
A study on chemical composition and detection of chemical adulteration in tetra pack milk samples commercially available in Multan
The aim of this study was to analyze and compare the chemical composition of 8 tetra pack milk samples, Olpers (S1), Haleeb (S2), Good milk (S3), Everyday (S4), Milk Pack (S5), Dairy Queen (S6), Dairy Umang (S7), N...