CORRELATION OF PLATELET VOLUME INDICES (PVI) WITH SPECTRUM OF CORONARY ARTERY DISEASE: A PROSPECTIVE STUDY IN INDIAN SCENARIO
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2016, Vol 5, Issue 35
Abstract
BACKGROUND Coronary artery disease is new epidemic of the current millennium and is the leading cause of death worldwide. Platelet size reflects its activity and have definitive role in causing its pathogenesis and its complications as larger platelets are metabolically and enzymatically more active. The aim of this study was to study Platelet Volume Indices (PVI) in the spectrum of coronary artery diseases. METHOD AND MATERIALS In this prospective study, 230 cases were studied. Group I- 100 patients with acute myocardial infarction (AMI) or unstable angina (UA). Group II-100 patients had stable coronary artery disease. Group III - 30 healthy and age matched controls from health checkup with no history of heart disease and normal electrocardiogram. The anticoagulated peripheral blood sample were collected from each patient and analysed in a 3-part semiautomated haematology analyser and PVI were tabulated. RESULTS All three Platelet indices, i.e. Mean Platelet Volume (MPV), Platelet Distribution Width (PDW) and Platelet to Large Cell Ratio (PLCR) were significantly increased in Group I and II. In group I mean PDW, MPV and P-LCR were 14.17 fL, 10.73 fL and 29.01% respectively. In group II mean PDW, MPV and P-LCR were 11.98 fL, 10.43 fL and 23.43% respectively. In group III mean PDW, MPV and P-LCR were 11.06 fL, 9.36 fL and 21.36% respectively. Cut off values for predicting acute coronary event for PDW, MPV and PLCR were 12.85 fL, 9.65 fL and 22.75% respectively. CONCLUSION PVI is routinely available, simple and cost effective tool for predicting possibility of impending acute events as larger platelets can easily be identified during routine haematological analysis and could possibly benefit from preventive treatment.
Authors and Affiliations
Rigvardhan , Nikhilesh , Rama , Nishant , Jyoti
Keywords
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- EP ID EP159598
- DOI 10.14260/jemds/2016/465
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