CORRELATION OF PLATELET VOLUME INDICES (PVI) WITH SPECTRUM OF CORONARY ARTERY DISEASE: A PROSPECTIVE STUDY IN INDIAN SCENARIO
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2016, Vol 5, Issue 35
Abstract
BACKGROUND Coronary artery disease is new epidemic of the current millennium and is the leading cause of death worldwide. Platelet size reflects its activity and have definitive role in causing its pathogenesis and its complications as larger platelets are metabolically and enzymatically more active. The aim of this study was to study Platelet Volume Indices (PVI) in the spectrum of coronary artery diseases. METHOD AND MATERIALS In this prospective study, 230 cases were studied. Group I- 100 patients with acute myocardial infarction (AMI) or unstable angina (UA). Group II-100 patients had stable coronary artery disease. Group III - 30 healthy and age matched controls from health checkup with no history of heart disease and normal electrocardiogram. The anticoagulated peripheral blood sample were collected from each patient and analysed in a 3-part semiautomated haematology analyser and PVI were tabulated. RESULTS All three Platelet indices, i.e. Mean Platelet Volume (MPV), Platelet Distribution Width (PDW) and Platelet to Large Cell Ratio (PLCR) were significantly increased in Group I and II. In group I mean PDW, MPV and P-LCR were 14.17 fL, 10.73 fL and 29.01% respectively. In group II mean PDW, MPV and P-LCR were 11.98 fL, 10.43 fL and 23.43% respectively. In group III mean PDW, MPV and P-LCR were 11.06 fL, 9.36 fL and 21.36% respectively. Cut off values for predicting acute coronary event for PDW, MPV and PLCR were 12.85 fL, 9.65 fL and 22.75% respectively. CONCLUSION PVI is routinely available, simple and cost effective tool for predicting possibility of impending acute events as larger platelets can easily be identified during routine haematological analysis and could possibly benefit from preventive treatment.
Authors and Affiliations
Rigvardhan , Nikhilesh , Rama , Nishant , Jyoti
Keywords
Related Articles
- EP ID EP159598
- DOI 10.14260/jemds/2016/465
- Views 81
- Downloads 0
A RARE CASE OF SMALL BOWEL PNEUMATOSIS INTESTINALIS PRESENTING WITH SHOCK- A CASE REPORT
PRESENTATION OF THE CASE An 82-year-old male presented to the emergency with complaints of abdominal distention, nausea and vomiting since the past 3 days. It was also associated with pain in the abdomen which was diffus...
OTONEUROLOGICAL MANIFESTATION IN SUBCLAVIAN STEAL SYNDROME
The subclavian steal syndrome is characterized by a subclavian artery stenosis located proximal to the origin of the vertebral artery. In this case, the subclavian artery steals reverse-flow blood from the vert...
ANT BITE: A RARE CAUSE OF ANAPHYLAXIS IN PREGNANCY
Anaphylaxis during pregnancy can be catastrophic for both mother and her fetus. Ant bites are a rare cause of anaphylaxis in pregnant females. The manifestations of anaphylaxis in pregnant females have unusual fe...
MICROBIOLOGICAL STUDY AND ANTIBIOGRAM IN CONGENITAL NASOLACRIMAL DUCT OBSTRUCTION- AT A TERTIARY CARE EYE HOSPITAL
BACKGROUND Commonest cause for congenital dacryocystitis is obstruction at the lower end of nasolacrimal duct. It is due to an imperforate membrane at the lower end of nasolacrimal duct and usually affects the babies wit...
COMPARATIVE DIAGNOSTIC STUDY ON BREAST LESIONS
BACKGROUND The aim of the study is to evaluate the breast lumps using ultrasound and mammogram independently and in combination. METHODS In this study group there were 30 patients, out of whom 29 were female an...