Cytotoxic flavonoids from the young twigs and leaves of Caesalpinia bonduc (Linn) Roxb
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 6
Abstract
The extraction, fractionation and recognition of flavonoids from the ethanolic extract of young twigs and leaves of C. bonduc were carried out. In addition, cytotoxic study of the flavonoids on two cancer cell lines, BGC-823 and HeLa was carried our using sulphorhodamine B assay. Seven flavonoids, six of which are being reported for the first time in this plant, were isolated. Their structures were identified by MS and NMR spectroscopic methods. Petroleum ether, ethyl acetate and water fractions exhibited moderate cytotoxic activity against HeLa cells. Five compounds showed cytotoxic activity against HeLa cell in comparison with Paclitaxel, while only one compound showed a good degree of cytotoxic activity against BGC-823 cell in comparison to Paclitaxel. The results obtained showed a structure - activity relationship.
Authors and Affiliations
Olubanke Olujoke Ogunlana , Wen Jun He , Jun Ting Fan , Guang Zhi Zeng , Chang Jiu Ji , Yu Quing Zheng , Joseph Abayomi Olagunju , Afolabi Akintunde Akindahunsi , Ning Hua Tan
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